Subependymal giant cell astrocytoma - tuberous sclerosis

Discussion:

Patient was being treated for seizure disorder and also had cutaneous manifestations of Tuberous Sclerosis.

There was h/o focal seizures in childhood. The patient also had Shagreen patches and adenoma sebaceum.  MRI done subsequently showed additional cortical tubers.

SGCA is the second most common manifestation of tuberous sclerosis (TS). First being tubers. It affects 5% of patients. The foramen of Monroe is the classic location. Some of the subependymal nodules themselves can transform into SGCA over a period of time.

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