Histopathology

Microscopic description

The provided slides show aggregates of histiocytes mixed with abundant eosinophils and lymphocytes. Nuclear grooves are also seen in some of the histiocytes. The provided immunostains show that these clusters of histiocytes are positive for CD1a. The morphology and immunoprofile support the diagnosis of Langerhans cell histiocytosis.

Diagnosis

Langerhans cell histiocytosis

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