Pseudocirrhosis without chemotherapy


Pseudocirrhosis most often is used to describe the morphologic changes of cirrhosis developing in patients with metastatic breast cancer after chemotherapy. It has also been described in other malignancies and in patients who have NOT received chemotherapy, as in this case.

However, in my literature search, I did not find any actual case reports with images of pseudocirrhosis without chemotherapy, indicating that this is actually quite rare. 

The pathophysiology of pseudocirrhosis can be due to scarring/capsular retraction following chemotherapy, desmoplastic reaction due to infiltrative active tumor, and nodular regenerative hyperplasia.1

In this case, the pathology report supports cholestatic liver injury, mass effect/outflow obstruction, and pericellular fibrosis as the cause of this appearance.