Liver (Random) Biopsy:
- Metastatic breast carcinoma
- ER/PR/HER2 positive
Sections of non-neoplastic liver reveals hepatic parenchyma containing intact bile ducts. There in no portal inflammation noted. Scattered lobular inflammation is seen. The parenchyma is notable for cholestasis with feathery degeneration of hepatocytes with rosette formation in areas of cholestasis. Mallory-Denk bodies, excess iron storage and hepatocellular protein globules are absent. Some of the hepatocytes appears to have a "small cell change"-like appearance with some areas exhibiting hepatic cord atrophy, while other areas have the appearance of hypertrophy. These changes likely represent findings secondary to mass effect and possible outflow obstruction. A trichrome-stained slide reveals focal periportal pericellular fibrosis. In situ hybridization for EBV encoded RNA (EBER) is negative.