Glioblastoma NOS (cystic)


This case demonstrates yet another appearance of GBMs. Often the peripheral enhancement is nodular and irregular representing heterogeneous necrosis of a solid tumor. In this case, the appearances are more those of a cystic tumor, with thin regular contrast enhancement. 


MICROSCOPIC DESCRIPTION: The sections show features of a densely cellular astrocytic tumor. The tumor cells show elongated, angulated and hyperchromatic nuclei. Scattered tumor giant cells are identified. Mitoses are present. There is focal mild endothelial cell hyperplasia. One area of palisaded necrosis is present. The features are those of glioblastoma multiforme.

DIAGNOSIS: Glioblastoma (WHO Grade IV).

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumors, this tumor would, therefore, be designated as a glioblastoma NOS