Oligoastrocytoma NOS (anaplastic)

Discussion:

This case illustrates a tumor with imaging features suggesting a low-grade glioma that showed to be a high-grade tumor in the histology. 

 

NOTE: This case predates the 2016 WHO classification of CNS tumor revision. As no 1p19q co-deletion status is available a formal diagnosis cannot be reached and the NOS is therefore used (not otherwise specified) - which is recognized in the current classification for cases where molecular information is unavailable. It should also be noted, that under the new classification both an astrocytic and oligodendroglial component needs to be identified, each with its own molecular markers. True oligoastrocytomas are therefore going to be rare, and this case would most likely be classified as either an astrocytoma or an oligodendroglioma. 

Case courtesy of Associate Professor Pramit Phal

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