50 year old man presented with typical ECG and laboratory diagnosis of acute myocardial infarction. Metalyse (tenecteplase) was administered in ICU. The patient developed sudden loss of conscious with GCS of 3. CT head done showed massive acute right parietal region parenchymal hemorrhage with fluid-fluid level in keeping with hematocrit effect. Hyperattenuating floating clots are seen within the hemorrhage.