Diffuse astrocytoma NOS ("protoplasmic")

Discussion:

This case represents a left frontal solid tumor involving the cortex and with features suggesting a low-grade glioma. The tumor was resected and confirmed as a protoplasmic astrocytoma

Note: Until recently, protoplasmic astrocytomas were classified as a subtype low-grade astrocytoma, however, in the latest (2016) update to WHO classification of CNS tumors, protoplasmic astrocytomas no longer exists as a distinct entity, but rather are considered as a pattern of certain gliomas, requiring IDH +/- 1p19q status for classification. 

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumors, this tumor would, therefore, be designated as a diffuse astrocytoma NOS.

 

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