Diffuse fibrillary astrocytoma

Discussion:

The patient went on to have a stereotactic biopsy. 

Histology

MICROSCOPIC DESCRIPTION: Paraffin sections show 9 cores of brain tissue. There is a mild increase in cell density and some architectural disturbance, most notably in the three cores in specimen 3. There is mild atypia of fibrillary astrocytes with aggregates of 2-4 nuclei noted and foci of perivascular secondary structuring. Scattered mature neurons are noted. Some of these also show secondary structuring. No mitotic figures are identified and there is no vascular endothelial cell hyperplasia and no necrosis. The features are of diffuse fibrillary astrocytoma, WHO Grade II.

FINAL DIAGNOSIS: 1 Diffuse fibrillary astrocytoma (WHO Grade II)

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