Ganglioneuroma

Discussion:

HISTOPATHOLOGY

Microscopic description
- Spindle cells dispersed in a myxoid background, those cells show wavy and serpentine nuclei. Also there are ganglion cells with large round nuclei, prominent nucleoli and abundunt cytoplasm. The tumor contains an abundunt fatty component with myxoid degeneration. Some entrapped nerve fibers are noted. No atypia or mitotic activity is evident. The ganglion cells stain positive for chromogranin and the spindle cells represent Schwann cells positive for S-100 protein. 
Ki-67 index is estimated to be less than 1%.

Diagnosis
- Ganglioneuroma with fatty component.
- No malignancy seen.

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