MACROSCOPIC DESCRIPTION: Six haemorrhagic gelatinous fragments.
MICROSCOPIC DESCRIPTION: The sections show an epithelioid tumour, forming cords, embedded in prominently myxomatous stroma. The tumour invades into the dura and there is full thickness involvement of the skull bone. The tumour cells have mildly enlarged and hyperchromatic ovoid nuclei, small nucleoli and small amounts of eosinophilic cytoplasm. Scattered physaliferous cells are seen and they show cytoplasmic vacuolation. Lymphovascular invasion is absent. The tumour cells are CAM5.2 and S-100 positive, in keeping with chordoma. The tumour appears to be clear of the outer dural and bony margins. The tumour on the outer part of the skull bone is covered by a layer of fibrous tissue and skeletal muscle. It has not infiltrated through this outer margin.
DIAGNOSIS: Metastatic chordoma, completely excised with clear dural and bony margins.