Osteopoikilosis

Discussion:

Osteopoikilosis is a rare, benign, asymptomatic and often incidental bone dysplasia.  It has an autosomal dominant inheritance.  Occasionally it can mistaken for osteoblastic metastases.  However, osteoblastic metastases are often non-uniform sclerotic foci.  Bone scans in osteopoikilosis are also normal which would further differentiate it from osteoblastic metastases.

Osteopoikilosis often favors the appendicular skeleton and rarely involves the ribs, clavicles and spine.1  This case is unique in that these sclerotic foci are seen in both the appendicular and axial skeleton.

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