Oligodendroglioma NOS

Discussion:

The patient went on to have a biopsy of the mass. 

Histology

Microscopic Description: 

Sections show a neoplasm comprised predominantly of small round cells demonstrating a minimal degree of pleomorphism and frequent perinuclear halos. No mitotic figures are evident. There is no endothelial proliferation and no necrosis is evident. Toluidine blue-stained plastic sections of the glutaraldehyde-fixed tissue show no additional findings.

Immunohistochemistry shows that scattered cells are positive for glial fibrillary acidic protein (GFAP). The lesion shows a uniform distribution of MIB-1 positive cells. No p53-positive cells were seen.

FINAL DIAGNOSIS:  This stereotactic brain biopsy shows histological features of a low-grade oligodendroglial tumor. Thus, the features are consistent with an oligodendroglioma.

Note: This case predates the recent (2016) revision WHO classification of CNS tumors, and thus molecular markers (IDH mutation and 1p19q co-deletion) are not available. As such, this tumor would now be classified as an oligodendroglioma NOS.

    Create a new playlist
Loading...