Cerebral metastasis - colorectal adenocarcinoma

Discussion:

The patient went on to have a resection.

Histology

MICROSCOPIC DESCRIPTION:

Sections of brain tissue show a cohesive tumor composed of mucin-secreting cribriform glands. Tumor cells contain abundant eosinophilic cytoplasm, vesicular nuclei and prominent nucleoli. Frequent mitoses and central necrosis are present.

Immunohistochemical results show tumor cells stain: CK7-, CK20+, TTF1- and CDX2+

FINAL DIAGNOSIS: Metastatic moderately differentiated adenocarcinoma, consistent with colorectal primary.

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