Giant cell tumor of bone - knee

Discussion:

Giant cell tumors (GCT) of bone, also known as osteoclastomas, probably arise from zones of intense osteoclastic activity. It comprises 4-9% of all primary bone tumors and 18-23% of benign bone tumors. The peak age of involvement is during the 3rd decade. It generally occurs after the closure of epiphysis, which is the main differentiating point from an aneurysmal bone cyst (ABC). It usually involves long bones, subarticular in location, eccentric with a soap bubble appearance. Periosteal reaction, narrow zone of transition, lack of soft tissue component involvement, narrow permeative zone, and benign nature of the presentation allow the lesion to be differentiated from osteosarcoma. MRI plays a vital role in the assessment of the lesion.

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