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WHO classification of haematolymphoid tumours

Changed by Frank Gaillard, 12 Mar 2023
Back to revision history
Disclosures - updated 6 Dec 2022:
  • Biogen Australia Pty Ltd, Investigator-Initiated Research Grant for CAD software in multiple sclerosis: finished Oct 2021 (past)

Updates to Article Attributes

Body was changed:

The World Health Organisation (WHO) classification of tumours of haematopoietic and lymphoid tissues is the most widely used pathologic classification system for hematolymphoid neoplasms. The current revision, known as the 5th edition, was published in 2022 and supersedes the 4th edition revised published in 2016.

IMPORTANT: We are in the process of updating this section. For now, the article below is a mixture of both 2016 and 2022 classifications 1-3.

Myeloid proliferations and neoplasms

Myeloid precursor lesion

  • clonal haematopoiesis

  • clonal cytopenias of undetermined significance

Myeloproliferative neoplasms
Mastocytosis

  • mastocytosis

    • cutaneous mastocytosis

    • systemic mastocytosis

    • mast cell sarcoma

Myelodysplastic neoplasms

  • myelodysplastic neoplasms, with defining genetic abnormalities

    • myelodysplastic neoplasm with low blasts and 5q deletion

    • myelodysplastic neoplasm with low blasts and SF3B1 mutation

    • myelodysplastic neoplasm with biallelic TP53 inactivation

  • myelodysplastic neoplasms, morphologically defined

    • myelodysplastic neoplasm with low blasts

    • myelodysplastic neoplasm, hypoplastic

    • myelodysplastic neoplasm with increased blasts

  • myelodysplastic neoplasms of childhood

    • childhood myelodysplastic neoplasm with low blasts

    • childhood myelodysplastic neoplasm with increased blasts

Myelodysplastic/myeloproliferative neoplasms

  • myelodysplastic/myeloproliferative neoplasms

    • chronic myelomonocytic leukaemia

    • myelodysplastic/myeloproliferative neoplasm with neutrophilia

    • myelodysplastic/myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis

    • myelodysplastic/myeloproliferative neoplasm, NOS

Acute myeloid leukaemia

  • acute myeloid leukaemia with defining genetic abnormalities

    • acute promyelocytic leukaemia with PML::RARA fusion

    • acute myeloid leukaemia with RUNX1::RUNX1T1 fusion

    • acute myeloid leukaemia with CBFB::MYH11 fusion

    • acute myeloid leukaemia with DEK::NUP214 fusion

    • acute myeloid leukaemia with RBM15::MRTFA fusion

    • acute myeloid leukaemia with BCR::ABL1 fusion

    • acute myeloid leukaemia with KMT2A rearrangement

    • acute myeloid leukaemia with MECOM rearrangement

    • acute myeloid leukaemia with NUP98 rearrangement

    • acute myeloid leukaemia with NPM1 mutation

    • acute myeloid leukaemia with CEBPA mutation

    • acute myeloid leukaemia, myelodysplasia-related

    • acute myeloid leukaemia with other defined genetic alterations

  • acute myeloid leukaemia, defined by differentiation

    • acute myeloid leukaemia with minimal differentiation

    • acute myeloid leukaemia without maturation

    • acute myeloid leukaemia with maturation

    • acute basophilic leukaemia

    • acute myelomonocytic leukaemia

    • acute monocytic leukaemia

    • acute erythroid leukaemia

    • acute megakaryoblastic leukaemia

  • myeloid sarcoma

Myeloid neoplasms, secondary

  • myeloid neoplasm post cytotoxic therapy

  • myeloid neoplasms associated with germline predisposition

  • myeloid proliferations associated with Down syndrome

Myeloid/lymphoid neoplasms

  • myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement

    • myeloid/lymphoid neoplasms with PDGFRA rearrangement

    • myeloid/lymphoid neoplasms with PDGFRB rearrangement

    • myeloid/lymphoid neoplasms with FGFR1 rearrangement

    • myeloid/lymphoid neoplasms with JAK2 rearrangement

    • myeloid/lymphoid neoplasm with FLT3 rearrangement

    • myeloid/lymphoid neoplasm with ETV6::ABL1 fusion

    • myeloid/lymphoid neoplasms with other tyrosine kinase gene fusions

Acute leukaemias of mixed or ambiguous lineage

  • acute leukaemia of ambiguous lineage with defining genetic abnormalities

    • mixed-phenotype acute leukaemia with BCR::ABL1 fusion

    • mixed-phenotype acute leukaemia with KMT2A rearrangement

    • acute leukaemia of ambiguous lineage with other defined genetic alterations

  • acute leukaemia of ambiguous lineage, immunophenotypically defined

    • mixed-phenotype acute leukaemia, B/myeloid

    • mixed-phenotype acute leukaemia, T/myeloid

    • mixed-phenotype acute leukaemia, rare types

    • acute leukaemia of ambiguous lineage, NOS

    • aute undifferentiated leukaemia

Histiocytic/dendritic cell neoplasms

Plasmacytoid dendritic cell neoplasms
Langerhans cell and other dendritic cell neoplasms
Histiocyte/macrophage neoplasms

2016 classification below this point

Lymphoid neoplasms
Tumour like lesions with B-cell predominance

See also

Precursor B-cell neoplasms

  • precursor lymphoid neoplasms

  • Histiocyte Society classification of histiocytosesB-lymphoblastic leukaemias/lymphomas

    • B-lymphoblastic leukaemia/lymphoma

    • non-Langerhans cell histiocytosisB-lymphoblastic leukaemia/lymphoma with high hyperdiploidy

    • B-lymphoblastic leukaemia/lymphoma with hypodiploidy

    • B-lymphoblastic leukaemia/lymphoma with iAMP21

    • B-lymphoblastic leukaemia/lymphoma with BCR::ABL1 fusion

    • B-lymphoblastic leukaemia/lymphoma with BCR::ABL1-like features

    • B lymphoblastic leukaemia/lymphoma with KMT2A rearrangement

    • B lymphoblastic leukaemia/lymphoma with ETV6::RUNX1 fusion

    • B-lymphoblastic leukaemia/lymphoma with ETV6::RUNX1-like features

    • B lymphoblastic leukaemia/lymphoma with TCF3::PBX1 fusion

    • B lymphoblastic leukaemia/lymphoma with IGH::IL3 fusion

    • B lymphoblastic leukaemia/lymphoma with TCF3::HLF fusion

    • B-lymphoblastic leukaemia/lymphoma with other defined genetic alterations

    • B-lymphoblastic leukaemia/lymphoma, NOS

Mature B-cell neoplasms
Hodgkin lymphoma
Plasma cell neoplasms and other diseases with paraproteins

T-cell and NK-cell lymphoid proliferations and lymphomas

Content pending

Stroma-derived neoplasms of lymphoid tissues

Content pending

Genetic tumour syndromes

Content pending

2016 classification below this point
  • -<p>The<strong> World Health Organisation (WHO) classification of tumours of haematopoietic and lymphoid tissues</strong> is the most widely used pathologic classification system for hematolymphoid neoplasms. The current revision, known as the 5<sup>th</sup> edition, was published in 2022 and supersedes the 4<sup>th </sup>edition revised published in 2016.</p><p><strong>IMPORTANT:</strong> We are in the process of updating this section. For now, the article below is a mixture of both 2016 and 2022 classifications <sup>1-3</sup>.</p><h4>Myeloid proliferations and neoplasms</h4><h5>Myeloid precursor lesion</h5><ul>
  • -<li><p>clonal haematopoiesis</p></li>
  • -<li><p>clonal cytopenias of undetermined significance</p></li>
  • -</ul><h5>Myeloproliferative neoplasms</h5><ul><li>
  • -<p><a href="/articles/myeloproliferative-neoplasm-1">myeloproliferative neoplasms</a></p>
  • -<ul>
  • -<li><p><a href="/articles/chronic-myeloid-leukaemia">chronic myeloid leukaemia</a></p></li>
  • -<li><p><a href="/articles/chronic-neutrophilic-leukemia">chronic neutrophilic leukaemia</a></p></li>
  • -<li><p>chronic eosinophilic leukaemia</p></li>
  • -<li><p><a href="/articles/polycythaemia-vera">polycythaemia vera</a></p></li>
  • -<li><p><a href="/articles/essential-thrombocythemia">essential thrombocythaemia</a></p></li>
  • -<li><p><a href="/articles/primary-myelofibrosis">primary myelofibrosis</a></p></li>
  • -<li><p>juvenile myelomonocytic leukaemia</p></li>
  • -<li><p>myeloproliferative neoplasm, <a href="/articles/not-otherwise-specified-nos" title="Not otherwise specified (NOS)">NOS</a></p></li>
  • -</ul>
  • -</li></ul><h5>Mastocytosis</h5><ul><li>
  • -<p><a href="/articles/mastocytosis">mastocytosis</a></p>
  • -<ul>
  • -<li><p>cutaneous mastocytosis</p></li>
  • -<li><p>systemic mastocytosis</p></li>
  • -<li><p>mast cell sarcoma</p></li>
  • -</ul>
  • -</li></ul><h5>Myelodysplastic neoplasms</h5><ul>
  • -<li>
  • -<p>myelodysplastic neoplasms, with defining genetic abnormalities</p>
  • -<ul>
  • -<li><p>myelodysplastic neoplasm with low blasts and 5q deletion</p></li>
  • -<li><p>myelodysplastic neoplasm with low blasts and SF3B1 mutation</p></li>
  • -<li><p>myelodysplastic neoplasm with biallelic TP53 inactivation</p></li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p>myelodysplastic neoplasms, morphologically defined</p>
  • -<ul>
  • -<li><p>myelodysplastic neoplasm with low blasts</p></li>
  • -<li><p>myelodysplastic neoplasm, hypoplastic</p></li>
  • -<li><p>myelodysplastic neoplasm with increased blasts</p></li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p>myelodysplastic neoplasms of childhood</p>
  • -<ul>
  • -<li><p>childhood myelodysplastic neoplasm with low blasts</p></li>
  • -<li><p>childhood myelodysplastic neoplasm with increased blasts</p></li>
  • -</ul>
  • -</li>
  • -</ul><h5>Myelodysplastic/myeloproliferative neoplasms</h5><ul><li>
  • -<p>myelodysplastic/myeloproliferative neoplasms</p>
  • -<ul>
  • -<li><p><a href="/articles/chronic-myelomonocytic-leukaemia">chronic myelomonocytic leukaemia</a></p></li>
  • -<li><p>myelodysplastic/myeloproliferative neoplasm with neutrophilia</p></li>
  • -<li><p>myelodysplastic/myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis</p></li>
  • -<li><p>myelodysplastic/myeloproliferative neoplasm, <a href="/articles/not-otherwise-specified-nos" title="Not otherwise specified (NOS)">NOS</a></p></li>
  • -</ul>
  • -</li></ul><h5>Acute myeloid leukaemia</h5><ul>
  • -<li>
  • -<p><a href="/articles/acute-myeloid-leukaemia">acute myeloid leukaemia</a> with defining genetic abnormalities</p>
  • -<ul>
  • -<li><p><a href="/articles/acute-promyelocytic-leukemia" title="Acute promyelocytic leukemia">acute promyelocytic leukaemia with <em>PML::RARA</em> fusion</a></p></li>
  • -<li><p>acute myeloid leukaemia with <em>RUNX1::RUNX1T1</em> fusion</p></li>
  • -<li><p>acute myeloid leukaemia with <em>CBFB::MYH11</em> fusion</p></li>
  • -<li><p>acute myeloid leukaemia with <em>DEK::NUP214</em> fusion</p></li>
  • -<li><p>acute myeloid leukaemia with <em>RBM15::MRTFA</em> fusion</p></li>
  • -<li><p>acute myeloid leukaemia with <em>BCR::ABL1</em> fusion</p></li>
  • -<li><p>acute myeloid leukaemia with <em>KMT2A</em> rearrangement</p></li>
  • -<li><p>acute myeloid leukaemia with <em>MECOM</em> rearrangement</p></li>
  • -<li><p>acute myeloid leukaemia with <em>NUP98</em> rearrangement</p></li>
  • -<li><p>acute myeloid leukaemia with <em>NPM1</em> mutation</p></li>
  • -<li><p>acute myeloid leukaemia with <em>CEBPA</em> mutation</p></li>
  • -<li><p>acute myeloid leukaemia, myelodysplasia-related</p></li>
  • -<li><p>acute myeloid leukaemia with other defined genetic alterations</p></li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p>acute myeloid leukaemia, defined by differentiation</p>
  • -<ul>
  • -<li><p>acute myeloid leukaemia with minimal differentiation</p></li>
  • -<li><p>acute myeloid leukaemia without maturation</p></li>
  • -<li><p>acute myeloid leukaemia with maturation</p></li>
  • -<li><p>acute basophilic leukaemia</p></li>
  • -<li><p>acute myelomonocytic leukaemia</p></li>
  • -<li><p>acute monocytic leukaemia</p></li>
  • -<li><p>acute erythroid leukaemia</p></li>
  • -<li><p>acute megakaryoblastic leukaemia</p></li>
  • -</ul>
  • -</li>
  • -<li><p><a href="/articles/myeloid-sarcoma-1">myeloid sarcoma</a></p></li>
  • -</ul><h5>Myeloid neoplasms, secondary</h5><ul>
  • -<li><p>myeloid neoplasm post cytotoxic therapy</p></li>
  • -<li><p>myeloid neoplasms associated with germline predisposition</p></li>
  • -<li><p>myeloid proliferations associated with <a href="/articles/down-syndrome">Down syndrome</a></p></li>
  • -</ul><h5>Myeloid/lymphoid neoplasms</h5><ul><li>
  • -<p>myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement</p>
  • -<ul>
  • -<li><p>myeloid/lymphoid neoplasms with <em>PDGFRA </em>rearrangement</p></li>
  • -<li><p>myeloid/lymphoid neoplasms with <em>PDGFRB </em>rearrangement</p></li>
  • -<li><p>myeloid/lymphoid neoplasms with <em>FGFR1 </em>rearrangement</p></li>
  • -<li><p>myeloid/lymphoid neoplasms with <em>JAK2 </em>rearrangement</p></li>
  • -<li><p>myeloid/lymphoid neoplasm with <em>FLT3</em> rearrangement</p></li>
  • -<li><p>myeloid/lymphoid neoplasm with <em>ETV6::ABL1</em> fusion</p></li>
  • -<li><p>myeloid/lymphoid neoplasms with other tyrosine kinase gene fusions</p></li>
  • -</ul>
  • -</li></ul><h5>Acute leukaemias of mixed or ambiguous lineage</h5><ul>
  • -<li>
  • -<p>acute leukaemia of ambiguous lineage with defining genetic abnormalities</p>
  • -<ul>
  • -<li><p>mixed-phenotype acute leukaemia with BCR::ABL1 fusion</p></li>
  • -<li><p>mixed-phenotype acute leukaemia with KMT2A rearrangement</p></li>
  • -<li><p>acute leukaemia of ambiguous lineage with other defined genetic alterations</p></li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p>acute leukaemia of ambiguous lineage, immunophenotypically defined</p>
  • -<ul>
  • -<li><p>mixed-phenotype acute leukaemia, B/myeloid</p></li>
  • -<li><p>mixed-phenotype acute leukaemia, T/myeloid</p></li>
  • -<li><p>mixed-phenotype acute leukaemia, rare types</p></li>
  • -<li><p>acute leukaemia of ambiguous lineage, <a href="/articles/not-otherwise-specified-nos" title="Not otherwise specified (NOS)">NOS</a></p></li>
  • -<li><p>aute undifferentiated leukaemia</p></li>
  • -</ul>
  • -</li>
  • -</ul><h4>Histiocytic/dendritic cell neoplasms</h4><h5>Plasmacytoid dendritic cell neoplasms</h5><ul><li>
  • -<p>plasmacytoid dendritic cell neoplasms</p>
  • -<ul>
  • -<li><p>mature plasmacytoid dendritic cell proliferation associated with myeloid neoplasm</p></li>
  • -<li><p><a href="/articles/blastic-plasmacytoid-dendritic-cell-neoplasm">blastic plasmacytoid dendritic cell neoplasm</a></p></li>
  • -</ul>
  • -</li></ul><h5>Langerhans cell and other dendritic cell neoplasms</h5><ul>
  • -<li>
  • -<p>Langerhans cells neoplasms</p>
  • -<ul>
  • -<li><p><a href="/articles/langerhans-cell-histiocytosis">Langerhans cell histiocytosis</a></p></li>
  • -<li><p><a href="/articles/langerhans-cell-sarcoma">Langerhans cell sarcoma</a></p></li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p>other dendritic cell neoplasms</p>
  • -<ul>
  • -<li><p>indeterminate dendritic cell tumour</p></li>
  • -<li><p>interdigitating dendritic cell sarcoma</p></li>
  • -</ul>
  • -</li>
  • -</ul><h5>Histiocyte/macrophage neoplasms</h5><ul><li>
  • -<p>histiocytic neoplasms</p>
  • -<ul>
  • -<li><p><a href="/articles/juvenile-xanthogranuloma" title="juvenile xanthogranuloma">juvenile xanthogranuloma</a></p></li>
  • -<li><p><a href="/articles/erdheim-chester-disease">Erdheim-Chester disease</a></p></li>
  • -<li><p><a href="/articles/rosai-dorfman-disease" title="Rosai-Dorfman disease">Rosai-Dorfman Disease</a></p></li>
  • -<li><p><a href="/articles/alk-positive-histiocytosis" title="ALK-positive histiocytosis">ALK-positive histiocytosis</a></p></li>
  • -<li><p><a href="/articles/histiocytic-sarcoma">histiocytic sarcoma</a></p></li>
  • -</ul>
  • -</li></ul><p></p><h4>2016 classification below this point</h4><p></p><p></p><p></p><p></p><h5>Lymphoid neoplasms</h5><ul>
  • -<li>
  • -<p><a href="/articles/acute-lymphoblastic-leukaemia">precursor lymphoid neoplasms</a></p>
  • -<ul>
  • -<li>
  • -<p>B-lymphoblastic leukaemia/lymphoma</p>
  • -<ul>
  • -<li><p>B-lymphoblastic leukaemia/lymphoma, not otherwise specified</p></li>
  • -<li>
  • -<p>B-lymphoblastic leukaemia/lymphoma with recurrent genetic abnormalities</p>
  • -<ul>
  • -<li><p>B-lymphoblastic leukaemia/lymphoma with t(9;22)(q34.1;q11.2); <em>BCR-ABL1</em></p></li>
  • -<li><p>B-lymphoblastic leukaemia/lymphoma with t(v;11q23.3); <em>KMT2A</em> rearranged</p></li>
  • -<li><p>B-lymphoblastic leukaemia/lymphoma with t(12;21)(p13.2;q22.1); <em>ETV6-RUNX1</em></p></li>
  • -<li><p>B-lymphoblastic leukaemia/lymphoma with hyperdiploidy</p></li>
  • -<li><p>B-lymphoblastic leukaemia/lymphoma with hypodiploidy</p></li>
  • -<li><p>B-lymphoblastic leukaemia/lymphoma with t(5;14)(q31.1;q32.3); <em>IL3-IGH</em></p></li>
  • -<li><p>B-lymphoblastic leukaemia/lymphoma with t(1;19)(q23;p13.3); <em>TCF3-PBX1</em></p></li>
  • -<li><p>B-lymphoblastic leukaemia/lymphoma, <em>BCR-ABL1</em>–like (provisional entity)</p></li>
  • -<li><p>B-lymphoblastic leukaemia/lymphoma with iAMP21 (provisional entity)</p></li>
  • -</ul>
  • -</li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p>T-lymphoblastic leukaemia/lymphoma</p>
  • -<ul><li><p>early T-cell precursor lymphoblastic leukaemia (provisional entity)</p></li></ul>
  • -</li>
  • -<li><p>natural killer (NK) cell lymphoblastic leukaemia/lymphoma (provisional entity)</p></li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p>mature B-cell neoplasms</p>
  • -<ul>
  • -<li><p><a href="/articles/chronic-lymphocytic-leukaemia">chronic lymphocytic leukaemia</a>/<a href="/articles/small-lymphocytic-lymphoma">small lymphocytic lymphoma</a></p></li>
  • -<li><p>monoclonal B-cell lymphocytosis</p></li>
  • -<li><p>B-cell prolymphocytic leukaemia</p></li>
  • -<li><p><a href="/articles/splenic-marginal-zone-lymphoma">splenic marginal zone lymphoma</a></p></li>
  • -<li><p><a href="/articles/hairy-cell-leukaemia" title="Hairy cell leukaemia">hairy cell leukaemia</a></p></li>
  • -<li>
  • -<p><a href="/articles/splenic-lymphoma">splenic B-cell lymphoma/leukaemia, unclassifiable</a></p>
  • -<ul>
  • -<li><p>splenic diffuse red pulp small B-cell lymphoma (provisional entity)</p></li>
  • -<li><p>hairy cell leukaemia-variant (provisional entity)</p></li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p><a href="/articles/lymphoplasmacytic-lymphoma">lymphoplasmacytic lymphoma</a></p>
  • -<ul><li><p><a href="/articles/waldenstrom-macroglobulinaemia">Waldenström macroglobulinaemia</a></p></li></ul>
  • -</li>
  • -<li><p>IgM <a href="/articles/monoclonal-gammopathy-of-undetermined-significance">monoclonal gammopathy of undetermined significance</a></p></li>
  • -<li>
  • -<p>heavy-chain diseases</p>
  • -<ul>
  • -<li><p>μ heavy-chain disease</p></li>
  • -<li><p>γ heavy-chain disease</p></li>
  • -<li><p>α heavy-chain disease</p></li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p>plasma cell neoplasms</p>
  • -<ul>
  • -<li><p>non-IgM <a href="/articles/monoclonal-gammopathy-of-undetermined-significance">monoclonal gammopathy of undetermined significance</a> (IgG/A)</p></li>
  • -<li><p><a href="/articles/multiple-myeloma-1">plasma cell myeloma</a> (a.k.a. multiple myeloma)</p></li>
  • -<li>
  • -<p>plasma cell myeloma variants</p>
  • -<ul>
  • -<li><p><a href="/articles/smouldering-multiple-myeloma">smouldering (asymptomatic) plasma cell myeloma</a></p></li>
  • -<li><p><a href="/articles/non-secretory-myeloma">non-secretory myeloma</a></p></li>
  • -<li><p><a href="/articles/plasma-cell-leukaemia" title="Plasma cell leukaemia">plasma cell leukaemia</a></p></li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p><a href="/articles/plasmacytoma">plasmacytoma</a></p>
  • -<ul>
  • -<li><p><a href="/articles/solitary-bone-plasmacytoma-1">solitary plasmacytoma of bone</a></p></li>
  • -<li><p><a href="/articles/extramedullary-plasmacytoma">extraosseous plasmacytoma</a></p></li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p>monoclonal immunoglobulin deposition diseases</p>
  • -<ul>
  • -<li><p>primary <a href="/articles/amyloidosis">amyloidosis</a></p></li>
  • -<li><p><a href="/articles/light-chain-deposition-disease">light chain</a> and heavy chain deposition diseases</p></li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p>plasma cell neoplasms with associated paraneoplastic syndrome</p>
  • -<ul>
  • -<li><p><a href="/articles/poems-syndrome">POEMS syndrome</a></p></li>
  • -<li><p>TEMPI syndrome</p></li>
  • -</ul>
  • -</li>
  • -</ul>
  • -</li>
  • -<li><p><a href="/articles/malt-lymphoma">extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)</a></p></li>
  • -<li>
  • -<p>nodal <a href="/articles/marginal-zone-lymphoma">marginal zone lymphoma</a></p>
  • -<ul><li><p>paediatric nodal marginal zone lymphoma (provisional entity)</p></li></ul>
  • -</li>
  • -<li>
  • -<p><a href="/articles/follicular-lymphoma">follicular lymphoma</a></p>
  • -<ul>
  • -<li><p>testicular follicular lymphoma</p></li>
  • -<li><p>in situ follicular neoplasia</p></li>
  • -<li><p>duodenal-type follicular lymphoma</p></li>
  • -</ul>
  • -</li>
  • -<li><p>paediatric-type follicular lymphoma</p></li>
  • -<li><p>large B-cell lymphoma with <em>IRF4</em> rearrangement (provisional entity)</p></li>
  • -<li><p>primary cutaneous follicle centre lymphoma</p></li>
  • -<li>
  • -<p><a href="/articles/mantle-cell-lymphoma">mantle cell lymphoma</a></p>
  • -<ul>
  • -<li><p>leukaemic non-nodal mantle cell lymphoma</p></li>
  • -<li><p>in situ mantle cell neoplasia</p></li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p>diffuse large B-cell lymphoma, not otherwise specified</p>
  • -<ul>
  • -<li><p>germinal centre B-cell type</p></li>
  • -<li><p>activated B-cell type</p></li>
  • -</ul>
  • -</li>
  • -<li><p>T-cell/histiocyte-rich large B-cell lymphoma</p></li>
  • -<li><p><a href="/articles/lymphomas-of-the-central-nervous-system">primary diffuse large B-cell lymphoma of the central nervous system</a></p></li>
  • -<li><p>primary cutaneous diffuse large B-cell lymphoma, leg type</p></li>
  • -<li><p><a href="/articles/ebv-positive-diffuse-large-b-cell-lymphoma-nos">EBV-positive diffuse large B-cell lymphoma, not otherwise specified</a></p></li>
  • -<li><p>EBV-positive mucocutaneous ulcer (provisional entity)</p></li>
  • -<li>
  • -<p>diffuse large B-cell lymphoma associated with chronic inflammation</p>
  • -<ul><li><p>fibrin-associated diffuse large B-cell lymphoma</p></li></ul>
  • -</li>
  • -<li><p><a href="/articles/lymphomatoid-granulomatosis">lymphomatoid granulomatosis</a></p></li>
  • -<li><p><a href="/articles/primary-mediastinal-large-b-cell-lymphoma">primary mediastinal (thymic) large B-cell lymphoma</a></p></li>
  • -<li><p>intravascular large B-cell lymphoma</p></li>
  • -<li><p><a href="/articles/alk-positive-large-b-cell-lymphoma">ALK-positive large B-cell lymphoma</a></p></li>
  • -<li><p><a href="/articles/plasmablastic-lymphoma">plasmablastic lymphoma</a></p></li>
  • -<li><p><a href="/articles/primary-effusion-lymphoma">primary effusion lymphoma</a></p></li>
  • -<li>
  • -<p>HHV8-associated lymphoproliferative disorders</p>
  • -<ul>
  • -<li><p>multicentric <a href="/articles/castleman-disease">Castleman disease</a></p></li>
  • -<li><p>HHV8-positive diffuse large B-cell lymphoma, not otherwise specified (provisional entity)</p></li>
  • -<li><p>HHV8-positive germinotropic lymphoproliferative disorder</p></li>
  • -</ul>
  • -</li>
  • -<li><p><a href="/articles/burkitt-lymphoma">Burkitt lymphoma</a></p></li>
  • -<li><p>Burkitt-like lymphoma with 11q aberration (provisional entity)</p></li>
  • -<li>
  • -<p>high-grade B-cell lymphoma</p>
  • -<ul>
  • -<li><p>high-grade B-cell lymphoma with <em>MYC </em>and <em>BCL2 </em>and/or <em>BCL6 </em>rearrangements</p></li>
  • -<li><p>high-grade B-cell lymphoma, not otherwise specified</p></li>
  • -</ul>
  • -</li>
  • -<li><p>B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma</p></li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p>mature T- and NK-cell neoplasms</p>
  • -<ul>
  • -<li><p><a href="/articles/t-cell-prolymphocytic-leukaemia-1">T-cell prolymphocytic leukaemia</a></p></li>
  • -<li><p>T-cell large granular lymphocytic leukaemia</p></li>
  • -<li><p>chronic lymphoproliferative disorder of NK cells (provisional entity)</p></li>
  • -<li><p>aggressive NK-cell leukaemia</p></li>
  • -<li>
  • -<p>EBV-positive T-cell and NK-cell lymphoproliferative diseases of childhood</p>
  • -<ul>
  • -<li><p>systemic EBV-positive T-cell lymphoma of childhood</p></li>
  • -<li><p>chronic active EBV infection of T- and NK-cell type, systemic form</p></li>
  • -<li><p>hydroa vacciniforme–like lymphoproliferative disorder</p></li>
  • -<li><p>severe mosquito bite allergy</p></li>
  • -</ul>
  • -</li>
  • -<li><p>adult T-cell leukaemia/lymphoma</p></li>
  • -<li><p>extranodal NK-/T-cell lymphoma, nasal type</p></li>
  • -<li>
  • -<p>intestinal T-cell lymphoma</p>
  • -<ul>
  • -<li><p>enteropathy-associated T-cell lymphoma</p></li>
  • -<li><p>monomorphic epitheliotropic intestinal T-cell lymphoma</p></li>
  • -<li><p>intestinal T-cell lymphoma, not otherwise specified</p></li>
  • -<li><p>indolent T-cell lymphoproliferative disorder of the gastrointestinal tract (provisional entity)</p></li>
  • -</ul>
  • -</li>
  • -<li><p>hepatosplenic T-cell lymphoma</p></li>
  • -<li><p>subcutaneous panniculitis-like T-cell lymphoma</p></li>
  • -<li><p><a href="/articles/mycosis-fungoides" title="Mycosis fungoides">mycosis fungoides</a></p></li>
  • -<li><p><a href="/articles/sezary-syndrome-1">Sézary syndrome</a></p></li>
  • -<li>
  • -<p>primary cutaneous CD30+ T-cell lymphoproliferative disorders</p>
  • -<ul>
  • -<li><p>lymphomatoid papulosis</p></li>
  • -<li><p>primary cutaneous anaplastic large cell lymphoma</p></li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p>primary cutanoue peripheral T-cell lymphomas, rare subtypes</p>
  • -<ul>
  • -<li><p>primary cutaneous γδ T-cell lymphoma</p></li>
  • -<li><p>primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (provisional entity)</p></li>
  • -<li><p>primary cutaneous acral CD8+ T-cell lymphoma (provisional entity)</p></li>
  • -<li><p>primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (provisional entity)</p></li>
  • -</ul>
  • -</li>
  • -<li><p><a href="/articles/peripheral-t-cell-lymphoma">peripheral T-cell lymphoma</a>, not otherwise specified</p></li>
  • -<li>
  • -<p>angioimmunoblastic T-cell lymphoma and other nodal lymphomas of T follicular helper cell origin</p>
  • -<ul>
  • -<li><p><a href="/articles/angioimmunoblastic-t-cell-lymphoma">angioimmunoblastic T-cell lymphoma</a></p></li>
  • -<li><p>follicular T-cell lymphoma (provisional entity)</p></li>
  • -<li><p>nodal peripheral T-cell lymphoma with T follicular helper<em> </em>phenotype (provisional entity)</p></li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p><a href="/articles/anaplastic-large-cell-lymphoma-alkalk">anaplastic large-cell lymphoma</a></p>
  • -<ul>
  • -<li><p>anaplastic large-cell lymphoma, ALK-positive</p></li>
  • -<li><p>anaplastic large-cell lymphoma, ALK-negative</p></li>
  • -<li><p><a href="/articles/breast-implant-associated-anaplastic-large-cell-lymphoma-2">breast implant-associated anaplastic large-cell lymphoma</a> </p></li>
  • -</ul>
  • -</li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p><a href="/articles/hodgkin-lymphoma">Hodgkin lymphoma</a></p>
  • -<ul>
  • -<li><p>nodular lymphocyte predominant Hodgkin lymphoma</p></li>
  • -<li>
  • -<p>classical Hodgkin lymphoma</p>
  • -<ul>
  • -<li><p>nodular sclerosis classical Hodgkin lymphoma</p></li>
  • -<li><p>lymphocyte-rich classical Hodgkin lymphoma</p></li>
  • -<li><p>mixed cellularity classical Hodgkin lymphoma</p></li>
  • -<li><p>lymphocyte-depleted classical Hodgkin lymphoma</p></li>
  • -</ul>
  • -</li>
  • -</ul>
  • -</li>
  • -<li>
  • -<p><a href="/articles/posttransplant-lymphoproliferative-disorder">posttransplant lymphoproliferative disorders</a> (PTLD)</p>
  • -<ul>
  • -<li><p>plasmacytic hyperplasia PTLD</p></li>
  • -<li><p>infectious mononucleosis PTLD</p></li>
  • -<li><p>florid follicular hyperplasia PTLD</p></li>
  • -<li><p>polymorphic PTLD</p></li>
  • -<li>
  • -<p>monomorphic PTLD</p>
  • -<ul>
  • -<li><p>monomorphic B-cell PTLD</p></li>
  • -<li><p>monomorphic T/NK-cell PTLD</p></li>
  • -</ul>
  • -</li>
  • -<li><p>classical Hodgkin lymphoma PTLD</p></li>
  • -</ul>
  • -</li>
  • -</ul><h5></h5><h4>See also</h4><ul>
  • -<li><p><a href="/articles/lymphoma">lymphoma (general)</a></p></li>
  • -<li><p><a href="/articles/histiocyte-society-classification-of-histiocytoses">Histiocyte Society classification of histiocytoses</a></p></li>
  • -<li><p><a href="/articles/erdheim-chester-disease">non-Langerhans cell histiocytosis</a></p></li>
  • +<p>The<strong> World Health Organisation (WHO) classification of tumours of haematopoietic and lymphoid tissues</strong> is the most widely used pathologic classification system for hematolymphoid neoplasms. The current revision, known as the 5<sup>th</sup> edition, was published in 2022 and supersedes the 4<sup>th </sup>edition revised published in 2016.</p><p><strong>IMPORTANT:</strong> We are in the process of updating this section. For now, the article below is a mixture of both 2016 and 2022 classifications <sup>1</sup>.</p><h4>Myeloid proliferations and neoplasms</h4><h5>Myeloid precursor lesion</h5><ul>
  • +<li><p>clonal haematopoiesis</p></li>
  • +<li><p>clonal cytopenias of undetermined significance</p></li>
  • +</ul><h5>Myeloproliferative neoplasms</h5><ul><li>
  • +<p><a href="/articles/myeloproliferative-neoplasm-1">myeloproliferative neoplasms</a></p>
  • +<ul>
  • +<li><p><a href="/articles/chronic-myeloid-leukaemia">chronic myeloid leukaemia</a></p></li>
  • +<li><p><a href="/articles/chronic-neutrophilic-leukemia">chronic neutrophilic leukaemia</a></p></li>
  • +<li><p>chronic eosinophilic leukaemia</p></li>
  • +<li><p><a href="/articles/polycythaemia-vera">polycythaemia vera</a></p></li>
  • +<li><p><a href="/articles/essential-thrombocythemia">essential thrombocythaemia</a></p></li>
  • +<li><p><a href="/articles/primary-myelofibrosis">primary myelofibrosis</a></p></li>
  • +<li><p>juvenile myelomonocytic leukaemia</p></li>
  • +<li><p>myeloproliferative neoplasm, <a href="/articles/not-otherwise-specified-nos" title="Not otherwise specified (NOS)">NOS</a></p></li>
  • +</ul>
  • +</li></ul><h5>Mastocytosis</h5><ul><li>
  • +<p><a href="/articles/mastocytosis">mastocytosis</a></p>
  • +<ul>
  • +<li><p>cutaneous mastocytosis</p></li>
  • +<li><p>systemic mastocytosis</p></li>
  • +<li><p>mast cell sarcoma</p></li>
  • +</ul>
  • +</li></ul><h5>Myelodysplastic neoplasms</h5><ul>
  • +<li>
  • +<p>myelodysplastic neoplasms, with defining genetic abnormalities</p>
  • +<ul>
  • +<li><p>myelodysplastic neoplasm with low blasts and 5q deletion</p></li>
  • +<li><p>myelodysplastic neoplasm with low blasts and SF3B1 mutation</p></li>
  • +<li><p>myelodysplastic neoplasm with biallelic TP53 inactivation</p></li>
  • +</ul>
  • +</li>
  • +<li>
  • +<p>myelodysplastic neoplasms, morphologically defined</p>
  • +<ul>
  • +<li><p>myelodysplastic neoplasm with low blasts</p></li>
  • +<li><p>myelodysplastic neoplasm, hypoplastic</p></li>
  • +<li><p>myelodysplastic neoplasm with increased blasts</p></li>
  • +</ul>
  • +</li>
  • +<li>
  • +<p>myelodysplastic neoplasms of childhood</p>
  • +<ul>
  • +<li><p>childhood myelodysplastic neoplasm with low blasts</p></li>
  • +<li><p>childhood myelodysplastic neoplasm with increased blasts</p></li>
  • +</ul>
  • +</li>
  • +</ul><h5>Myelodysplastic/myeloproliferative neoplasms</h5><ul><li>
  • +<p>myelodysplastic/myeloproliferative neoplasms</p>
  • +<ul>
  • +<li><p><a href="/articles/chronic-myelomonocytic-leukaemia">chronic myelomonocytic leukaemia</a></p></li>
  • +<li><p>myelodysplastic/myeloproliferative neoplasm with neutrophilia</p></li>
  • +<li><p>myelodysplastic/myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis</p></li>
  • +<li><p>myelodysplastic/myeloproliferative neoplasm, <a href="/articles/not-otherwise-specified-nos" title="Not otherwise specified (NOS)">NOS</a></p></li>
  • +</ul>
  • +</li></ul><h5>Acute myeloid leukaemia</h5><ul>
  • +<li>
  • +<p><a href="/articles/acute-myeloid-leukaemia">acute myeloid leukaemia</a> with defining genetic abnormalities</p>
  • +<ul>
  • +<li><p><a href="/articles/acute-promyelocytic-leukemia" title="Acute promyelocytic leukemia">acute promyelocytic leukaemia with <em>PML::RARA</em> fusion</a></p></li>
  • +<li><p>acute myeloid leukaemia with <em>RUNX1::RUNX1T1</em> fusion</p></li>
  • +<li><p>acute myeloid leukaemia with <em>CBFB::MYH11</em> fusion</p></li>
  • +<li><p>acute myeloid leukaemia with <em>DEK::NUP214</em> fusion</p></li>
  • +<li><p>acute myeloid leukaemia with <em>RBM15::MRTFA</em> fusion</p></li>
  • +<li><p>acute myeloid leukaemia with <em>BCR::ABL1</em> fusion</p></li>
  • +<li><p>acute myeloid leukaemia with <em>KMT2A</em> rearrangement</p></li>
  • +<li><p>acute myeloid leukaemia with <em>MECOM</em> rearrangement</p></li>
  • +<li><p>acute myeloid leukaemia with <em>NUP98</em> rearrangement</p></li>
  • +<li><p>acute myeloid leukaemia with <em>NPM1</em> mutation</p></li>
  • +<li><p>acute myeloid leukaemia with <em>CEBPA</em> mutation</p></li>
  • +<li><p>acute myeloid leukaemia, myelodysplasia-related</p></li>
  • +<li><p>acute myeloid leukaemia with other defined genetic alterations</p></li>
  • +</ul>
  • +</li>
  • +<li>
  • +<p>acute myeloid leukaemia, defined by differentiation</p>
  • +<ul>
  • +<li><p>acute myeloid leukaemia with minimal differentiation</p></li>
  • +<li><p>acute myeloid leukaemia without maturation</p></li>
  • +<li><p>acute myeloid leukaemia with maturation</p></li>
  • +<li><p>acute basophilic leukaemia</p></li>
  • +<li><p>acute myelomonocytic leukaemia</p></li>
  • +<li><p>acute monocytic leukaemia</p></li>
  • +<li><p>acute erythroid leukaemia</p></li>
  • +<li><p>acute megakaryoblastic leukaemia</p></li>
  • +</ul>
  • +</li>
  • +<li><p><a href="/articles/myeloid-sarcoma-1">myeloid sarcoma</a></p></li>
  • +</ul><h5>Myeloid neoplasms, secondary</h5><ul>
  • +<li><p>myeloid neoplasm post cytotoxic therapy</p></li>
  • +<li><p>myeloid neoplasms associated with germline predisposition</p></li>
  • +<li><p>myeloid proliferations associated with <a href="/articles/down-syndrome">Down syndrome</a></p></li>
  • +</ul><h5>Myeloid/lymphoid neoplasms</h5><ul><li>
  • +<p>myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement</p>
  • +<ul>
  • +<li><p>myeloid/lymphoid neoplasms with <em>PDGFRA </em>rearrangement</p></li>
  • +<li><p>myeloid/lymphoid neoplasms with <em>PDGFRB </em>rearrangement</p></li>
  • +<li><p>myeloid/lymphoid neoplasms with <em>FGFR1 </em>rearrangement</p></li>
  • +<li><p>myeloid/lymphoid neoplasms with <em>JAK2 </em>rearrangement</p></li>
  • +<li><p>myeloid/lymphoid neoplasm with <em>FLT3</em> rearrangement</p></li>
  • +<li><p>myeloid/lymphoid neoplasm with <em>ETV6::ABL1</em> fusion</p></li>
  • +<li><p>myeloid/lymphoid neoplasms with other tyrosine kinase gene fusions</p></li>
  • +</ul>
  • +</li></ul><h5>Acute leukaemias of mixed or ambiguous lineage</h5><ul>
  • +<li>
  • +<p>acute leukaemia of ambiguous lineage with defining genetic abnormalities</p>
  • +<ul>
  • +<li><p>mixed-phenotype acute leukaemia with BCR::ABL1 fusion</p></li>
  • +<li><p>mixed-phenotype acute leukaemia with KMT2A rearrangement</p></li>
  • +<li><p>acute leukaemia of ambiguous lineage with other defined genetic alterations</p></li>
  • +</ul>
  • +</li>
  • +<li>
  • +<p>acute leukaemia of ambiguous lineage, immunophenotypically defined</p>
  • +<ul>
  • +<li><p>mixed-phenotype acute leukaemia, B/myeloid</p></li>
  • +<li><p>mixed-phenotype acute leukaemia, T/myeloid</p></li>
  • +<li><p>mixed-phenotype acute leukaemia, rare types</p></li>
  • +<li><p>acute leukaemia of ambiguous lineage, <a href="/articles/not-otherwise-specified-nos" title="Not otherwise specified (NOS)">NOS</a></p></li>
  • +<li><p>aute undifferentiated leukaemia</p></li>
  • +</ul>
  • +</li>
  • +</ul><h4>Histiocytic/dendritic cell neoplasms</h4><h5>Plasmacytoid dendritic cell neoplasms</h5><ul><li>
  • +<p>plasmacytoid dendritic cell neoplasms</p>
  • +<ul>
  • +<li><p>mature plasmacytoid dendritic cell proliferation associated with myeloid neoplasm</p></li>
  • +<li><p><a href="/articles/blastic-plasmacytoid-dendritic-cell-neoplasm">blastic plasmacytoid dendritic cell neoplasm</a></p></li>
  • +</ul>
  • +</li></ul><h5>Langerhans cell and other dendritic cell neoplasms</h5><ul>
  • +<li>
  • +<p>Langerhans cells neoplasms</p>
  • +<ul>
  • +<li><p><a href="/articles/langerhans-cell-histiocytosis">Langerhans cell histiocytosis</a></p></li>
  • +<li><p><a href="/articles/langerhans-cell-sarcoma">Langerhans cell sarcoma</a></p></li>
  • +</ul>
  • +</li>
  • +<li>
  • +<p>other dendritic cell neoplasms</p>
  • +<ul>
  • +<li><p>indeterminate dendritic cell tumour</p></li>
  • +<li><p>interdigitating dendritic cell sarcoma</p></li>
  • +</ul>
  • +</li>
  • +</ul><h5>Histiocyte/macrophage neoplasms</h5><ul><li>
  • +<p>histiocytic neoplasms</p>
  • +<ul>
  • +<li><p><a href="/articles/juvenile-xanthogranuloma" title="juvenile xanthogranuloma">juvenile xanthogranuloma</a></p></li>
  • +<li><p><a href="/articles/erdheim-chester-disease">Erdheim-Chester disease</a></p></li>
  • +<li><p><a href="/articles/rosai-dorfman-disease" title="Rosai-Dorfman disease">Rosai-Dorfman Disease</a></p></li>
  • +<li><p><a href="/articles/alk-positive-histiocytosis" title="ALK-positive histiocytosis">ALK-positive histiocytosis</a></p></li>
  • +<li><p><a href="/articles/histiocytic-sarcoma">histiocytic sarcoma</a></p></li>
  • +</ul>
  • +</li></ul><h4>B-cell lymphoid proliferations and lymphomas</h4><h5>Tumour like lesions with B-cell predominance</h5><ul>
  • +<li><p>reactive B-cell rich lymphoid proliferations that can mimic lymphoma</p></li>
  • +<li><p><a href="/articles/igg4-related-disease" title="IgG4-related disease">IgG4-related disease</a></p></li>
  • +<li><p><a href="/articles/unicentric-castleman-disease" title="Unicentric Castleman disease">unicentric Castleman disease</a></p></li>
  • +<li><p>idiopathic multicentric <a href="/articles/castleman-disease" title="Castleman disease">Castleman disease</a></p></li>
  • +<li><p>KSHV/HHV8-associated multicentric <a href="/articles/castleman-disease" title="Castleman disease">Castleman disease</a></p></li>
  • +</ul><h5>Precursor B-cell neoplasms</h5><ul>
  • +<li><p><a href="/articles/acute-lymphoblastic-leukaemia">precursor lymphoid neoplasms</a></p></li>
  • +<li>
  • +<p>B-lymphoblastic leukaemias/lymphomas</p>
  • +<ul>
  • +<li><p>B-lymphoblastic leukaemia/lymphoma</p></li>
  • +<li><p>B-lymphoblastic leukaemia/lymphoma with high hyperdiploidy</p></li>
  • +<li><p>B-lymphoblastic leukaemia/lymphoma with hypodiploidy</p></li>
  • +<li><p>B-lymphoblastic leukaemia/lymphoma with <em>iAMP21</em></p></li>
  • +<li><p>B-lymphoblastic leukaemia/lymphoma with <em>BCR::ABL1</em> fusion</p></li>
  • +<li><p>B-lymphoblastic leukaemia/lymphoma with <em>BCR::ABL1-like</em> features</p></li>
  • +<li><p>B lymphoblastic leukaemia/lymphoma with <em>KMT2A</em> rearrangement</p></li>
  • +<li><p>B lymphoblastic leukaemia/lymphoma with <em>ETV6::RUNX1</em> fusion</p></li>
  • +<li><p>B-lymphoblastic leukaemia/lymphoma with <em>ETV6::RUNX1-like</em> features</p></li>
  • +<li><p>B lymphoblastic leukaemia/lymphoma with <em>TCF3::PBX1</em> fusion</p></li>
  • +<li><p>B lymphoblastic leukaemia/lymphoma with<em> IGH::IL3 </em>fusion</p></li>
  • +<li><p>B lymphoblastic leukaemia/lymphoma with <em>TCF3::HLF</em> fusion</p></li>
  • +<li><p>B-lymphoblastic leukaemia/lymphoma with other defined genetic alterations</p></li>
  • +<li><p>B-lymphoblastic leukaemia/lymphoma, <a href="/articles/not-otherwise-specified-nos" title="Not otherwise specified (NOS)">NOS</a></p></li>
  • +</ul>
  • +</li>
  • +</ul><h5>Mature B-cell neoplasms</h5><ul>
  • +<li>
  • +<p>pre-neoplastic and neoplastic small lymphocytic proliferations</p>
  • +<ul>
  • +<li><p>monoclonal B-cell lymphocytosis</p></li>
  • +<li><p><a href="/articles/chronic-lymphocytic-leukaemia">chronic lymphocytic leukaemia</a>/<a href="/articles/small-lymphocytic-lymphoma">small lymphocytic lymphoma</a></p></li>
  • +</ul>
  • +</li>
  • +<li>
  • +<p>splenic B-cell lymphomas and leukaemias</p>
  • +<ul>
  • +<li><p><a href="/articles/hairy-cell-leukaemia" title="Hairy cell leukaemia">hairy cell leukaemia</a></p></li>
  • +<li><p><a href="/articles/splenic-marginal-zone-lymphoma">splenic marginal zone lymphoma</a></p></li>
  • +<li><p>splenic diffuse red pulp small B-cell lymphoma</p></li>
  • +<li><p>splenic B-cell lymphoma/leukaemia with prominent nucleoli</p></li>
  • +</ul>
  • +</li>
  • +<li><p><a href="/articles/lymphoplasmacytic-lymphoma" title="Lymphoplasmacytic lymphoma">lymphoplasmacytic lymphoma</a></p></li>
  • +<li>
  • +<p><a href="/articles/marginal-zone-lymphoma" title="Marginal zone lymphoma">marginal zone lymphoma</a></p>
  • +<ul>
  • +<li><p><a href="/articles/malt-lymphoma" title="MALT lymphoma">extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue</a></p></li>
  • +<li><p>primary cutaneous marginal zone lymphoma</p></li>
  • +<li><p>nodal marginal zone lymphoma</p></li>
  • +<li><p>paediatric nodal marginal zone lymphoma</p></li>
  • +</ul>
  • +</li>
  • +<li>
  • +<p><a href="/articles/follicular-lymphoma" title="Follicular lymphoma">follicular lymphoma</a></p>
  • +<ul>
  • +<li><p>in situ follicular B-cell neoplasm</p></li>
  • +<li><p>follicular lymphoma</p></li>
  • +<li><p>paediatric-type follicular lymphoma</p></li>
  • +<li><p>duodenal-type follicular lymphoma</p></li>
  • +</ul>
  • +</li>
  • +<li>
  • +<p>cutaneous follicle centre lymphoma</p>
  • +<ul><li><p>primary cutaneous follicle centre lymphoma</p></li></ul>
  • +</li>
  • +<li>
  • +<p><a href="/articles/mantle-cell-lymphoma" title="Mantle cell lymphoma">mantle cell lymphoma</a></p>
  • +<ul>
  • +<li><p>in situ mantle cell neoplasm</p></li>
  • +<li><p><a href="/articles/mantle-cell-lymphoma" title="Mantle cell lymphoma">mantle cell lymphoma</a></p></li>
  • +<li><p>leukaemic non-nodal mantle cell lymphoma</p></li>
  • +</ul>
  • +</li>
  • +<li><p>transformations of indolent B-cell lymphomas</p></li>
  • +<li>
  • +<p>large B-cell lymphomas</p>
  • +<ul>
  • +<li><p>diffuse large B-cell lymphoma, <a href="/articles/not-otherwise-specified-nos" title="Not otherwise specified (NOS)">NOS</a></p></li>
  • +<li><p>T-cell/histiocyte-rich large B-cell lymphoma</p></li>
  • +<li><p>diffuse large B-cell lymphoma / high grade B-cell lymphoma with MYC and BCL2 rearrangements</p></li>
  • +<li><p>ALK-positive large B-cell lymphoma</p></li>
  • +<li><p>large B-cell lymphoma with IRF4 rearrangement</p></li>
  • +<li><p>high grade B-cell lymphoma with 11q aberrations</p></li>
  • +<li><p><a href="/articles/lymphomatoid-granulomatosis" title="Lymphomatoid granulomatosis">lymphomatoid granulomatosis</a></p></li>
  • +<li><p><a href="/articles/ebv-positive-diffuse-large-b-cell-lymphoma-nos" title="EBV-positive diffuse large B-cell lymphoma, NOS">EBV-positive diffuse large B-cell lymphoma</a></p></li>
  • +<li><p>diffuse large B-cell lymphoma associated with chronic inflammation</p></li>
  • +<li><p>fibrin-associated large B-cell lymphoma</p></li>
  • +<li><p>fluid overload-associated large B-cell lymphoma</p></li>
  • +<li><p><a href="/articles/plasmablastic-lymphoma" title="Plasmablastic lymphoma">plasmablastic lymphoma</a></p></li>
  • +<li><p><a href="/articles/primary-large-b-cell-lymphoma-of-immune-privileged-sites" title="primary large B-cell lymphoma of immune-privileged sites">primary large B-cell lymphoma of immune-privileged sites</a></p></li>
  • +<li><p>primary cutaneous diffuse large B-cell lymphoma, leg type</p></li>
  • +<li><p><a href="/articles/intravascular-lymphoma" title="intravascular large B-cell lymphoma">intravascular large B-cell lymphoma</a></p></li>
  • +<li><p><a href="/articles/primary-mediastinal-large-b-cell-lymphoma" title="Primary mediastinal large B-cell lymphoma">primary mediastinal large B-cell lymphoma</a></p></li>
  • +<li><p>mediastinal grey zone lymphoma</p></li>
  • +<li><p>high-grade B-cell lymphoma, <a href="/articles/not-otherwise-specified-nos" title="Not otherwise specified (NOS)">NOS</a></p></li>
  • +</ul>
  • +</li>
  • +<li><p><a href="/articles/burkitt-lymphoma" title="Burkitt lymphoma">Burkitt lymphoma</a></p></li>
  • +<li>
  • +<p>KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas</p>
  • +<ul>
  • +<li><p><a href="/articles/primary-effusion-lymphoma" title="Primary effusion lymphoma">primary effusion lymphoma</a></p></li>
  • +<li><p>KSHV/HHV8-positive diffuse large B-cell lymphoma</p></li>
  • +<li><p>KSHV/HHV8-positive germinotropic lymphoproliferative disorder</p></li>
  • +</ul>
  • +</li>
  • +<li>
  • +<p>lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation</p>
  • +<ul>
  • +<li><p>hyperplasias arising in immune deficiency/dysregulation</p></li>
  • +<li><p>polymorphic lymphoproliferative disorders arising in immune deficiency / dysregulation</p></li>
  • +<li><p>EBV-positive mucocutaneous ulcer</p></li>
  • +<li><p>lymphomas arising in immune deficiency / dysregulation</p></li>
  • +<li><p>inborn error of immunity-associated lymphoid proliferations and lymphomas</p></li>
  • +</ul>
  • +</li>
  • +</ul><h5>Hodgkin lymphoma</h5><ul>
  • +<li><p>classic <a href="/articles/hodgkin-lymphoma" title="Hodgkin lymphoma">Hodgkin lymphoma</a></p></li>
  • +<li><p>nodular lymphocyte predominant Hodgkin lymphoma</p></li>
  • +</ul><h5>Plasma cell neoplasms and other diseases with paraproteins</h5><ul>
  • +<li>
  • +<p>monoclonal gammopathies</p>
  • +<ul>
  • +<li><p>cold agglutinin disease</p></li>
  • +<li><p><a href="/articles/monoclonal-gammopathy-of-undetermined-significance">IgM monoclonal gammopathy of undetermined significance</a></p></li>
  • +<li><p>non-IgM monoclonal gammopathy of undetermined significance</p></li>
  • +<li><p>monoclonal gammopathy of renal significance</p></li>
  • +</ul>
  • +</li>
  • +<li>
  • +<p>diseases with monoclonal immunoglobulin deposition</p>
  • +<ul>
  • +<li><p><a href="/articles/amyloidosis" title="Amyloidosis">immunoglobulin-related (AL) amyloidosis</a></p></li>
  • +<li><p>monoclonal immunoglobulin deposition disease</p></li>
  • +</ul>
  • +</li>
  • +<li>
  • +<p>heavy chain diseases</p>
  • +<ul>
  • +<li><p>Mu heavy chain disease</p></li>
  • +<li><p>Gamma heavy chain disease</p></li>
  • +<li><p>Alpha heavy chain disease</p></li>
  • +</ul>
  • +</li>
  • +<li>
  • +<p>plasma cell neoplasms</p>
  • +<ul>
  • +<li><p><a href="/articles/plasmacytoma" title="Plasmacytoma">plasmacytoma</a></p></li>
  • +<li><p><a href="/articles/multiple-myeloma-1" title="Multiple myeloma">plasma cell myeloma / multiple myeloma</a></p></li>
  • +<li><p>plasma cell neoplasms with associated paraneoplastic syndrome</p></li>
  • +</ul>
  • +</li>
  • +</ul><h4>T-cell and NK-cell lymphoid proliferations and lymphomas</h4><p>Content pending</p><h4>Stroma-derived neoplasms of lymphoid tissues</h4><p>Content pending</p><h4>Genetic tumour syndromes</h4><p>Content pending</p><h4>2016 classification below this point</h4><ul>
  • +<li>
  • +<p></p>
  • +<ul>
  • +<li><p><a href="/articles/peripheral-t-cell-lymphoma">peripheral T-cell lymphoma</a>, not otherwise specified</p></li>
  • +<li>
  • +<p>angioimmunoblastic T-cell lymphoma and other nodal lymphomas of T follicular helper cell origin</p>
  • +<ul>
  • +<li><p><a href="/articles/angioimmunoblastic-t-cell-lymphoma">angioimmunoblastic T-cell lymphoma</a></p></li>
  • +<li><p>follicular T-cell lymphoma (provisional entity)</p></li>
  • +<li><p>nodal peripheral T-cell lymphoma with T follicular helper<em> </em>phenotype (provisional entity)</p></li>
  • +</ul>
  • +</li>
  • +<li>
  • +<p><a href="/articles/anaplastic-large-cell-lymphoma-alkalk">anaplastic large-cell lymphoma</a></p>
  • +<ul>
  • +<li><p>anaplastic large-cell lymphoma, ALK-positive</p></li>
  • +<li><p>anaplastic large-cell lymphoma, ALK-negative</p></li>
  • +<li><p><a href="/articles/breast-implant-associated-anaplastic-large-cell-lymphoma-2">breast implant-associated anaplastic large-cell lymphoma</a> </p></li>
  • +</ul>
  • +</li>
  • +</ul>
  • +</li>
  • +<li>
  • +<p><a href="/articles/posttransplant-lymphoproliferative-disorder">posttransplant lymphoproliferative disorders</a> (PTLD)</p>
  • +<ul>
  • +<li><p>plasmacytic hyperplasia PTLD</p></li>
  • +<li><p>infectious mononucleosis PTLD</p></li>
  • +<li><p>florid follicular hyperplasia PTLD</p></li>
  • +<li><p>polymorphic PTLD</p></li>
  • +<li>
  • +<p>monomorphic PTLD</p>
  • +<ul>
  • +<li><p>monomorphic B-cell PTLD</p></li>
  • +<li><p>monomorphic T/NK-cell PTLD</p></li>
  • +</ul>
  • +</li>
  • +<li><p>classical Hodgkin lymphoma PTLD</p></li>
  • +</ul>
  • +</li>

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