What is the classical triad for tuberous sclerosis?
CLASSIC TRIAD (Vogt, 1908) in only 29% of patients: (1) Facial angiofibroma (2) Epileptic seizures (3) Mental retardation
What are some common neurologic manifestations of tuberous sclerosis (TS)?
Four common CNS abnormalities are: Cortical tubers, subependymal nodules, subependymal giant cell astrocytomas (SGCAs), and white matter abnormalities. Except for SGCAs, these abnormalities can be seen in almost all patients with TS. White matter abnormalities in patients with TS include (a) superficial white matter abnormalities associated with cortical tubers, (b) radial white matter bands, and (c) cystlike white matter lesions.
Cortical tubers hyperintense on T2 and FLAIR sequences
Subependymal nodules isointense with white matter
Hyperintense radial white matter bands best appreciated on FLAIR sequences