Sarcoidosis with upper lobe fibrosis

Case contributed by Farah Abu Jebbeh
Diagnosis certain

Presentation

Known case sarcoidosis , presented with shortness of breath.

Patient Data

Age: 40 years
Gender: Male

Diffuse scattered granular and satellite shaped opacities, giving the galaxy sign appearance, seen bilaterally predominantly in upper lobes, with peripheral patchy ground glass opacities, and multiple bilateral peripheral perilymphatic subpleural nodules with beaded fissural appearance.

Multiple enlarged hilar and mediastinal lymph nodes are noted, some of them show coarse calcification, the largest seen subcarina measures about 3 cm in short axis.

Confluent symmetrical consolidative changes noted radiating from both hila toward the upper lobes, suggesting upper lobes fibrosis associated with surrounding architectural distortion.

No honeycombing or bronchiectasis. No pericardial or pleural effusion. No pneumothorax.

Features are suggestive of sarcoidosis complicated by upper lobe fibrosis.

pathology

Case Discussion

Sarcoidosis is an idiopathic systemic disorder of noncaseating granulomas.

Pulmonary sarcoidosis may progress to pulmonary fibrosis, in which the fibrotic changes have a mid and upper-lung predominance and can produce progressive massive fibrosis.

Sarcoidosis may involve other organs, including the spleen, brain, and rarely bone.

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