Portal biliopathy refers to biliary obstruction associated with cavernous transformation of portal vein secondary to portal vein thrombosis.

When the portal vein thrombosis fails to recanalize, multiple venous collaterals develop to bypass the obstructed portal vein resulting in portal cavernoma formation. These peri-biliary collateral vessels can cause extrinsic compression over the intra-hepatic or extra-hepatic bile ducts, resulting in obstructive jaundice.

Complications may include cholangitis or hemobilia.