Glioblastoma - IDH-1 wildtype

Discussion:
The right frontal mass was biopsied and turned out to be a GBM IDH1 wildtype. The contralateral non-enhancing calcifed left centrum seimovale lesion was unusual and the possibility of a transformed oligodendroglioma was raised however the immunohistochemistry did not suggest that. Given the multiplicity and presence of calcification, metastases were considered such as lung, mucinous GI, papillary thyroid, or osteosarcoma. In a female, breast and mucinous ovarian primaries should also be considered.
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