How might the appearance of primary CNS lymphoma differ in a patient with HIV/AIDS?
AIDS-related CNS lymphoma is more likely to demonstrate necrosis.
When primary CNS lymphoma involves the corpus callosum, what is a helpful way to distinguish from glioblastoma on imaging?
Glioblastoma is more likely to display hemorrhage, necrosis and heterogeneous enhancement. Additionally, glioblastoma is less likely to show uniform diffusion restriction on MR and uniform hyperdensity on CT.
MRI of the brain demonstrates an infiltrating mass encasing the ventricular system with extension along the ependymal surface. The mass is seen invading and crossing the corpus callosum. There is an additional mass noted in the right cerebellar hemisphere. The masses are slightly hypointense on T2WI with surrounding high signal. There is associated restricted diffusion and avid homogenous enhancement. On SWI, areas of susceptibility in the infratentorial mass were seen probably related to calcifications from treatment-related changes. Additionally seen is a right frontal ventricular shunt catheter.