In pancreatic lipomatosis, there is a fatty replacement of the pancreatic parenchyma, as an incidental finding in this study, in which it was performed for the follow-up of colon cancer. It is most often associated with obesity and aging. Frequent causes of pancreatic lipomatosis are metabolic (diabetes mellitus, hyperlipidemia), use of steroids, alcoholic hepatitis, and chronic pancreatitis. The differential diagnostic considerations include pancreatic agenesis or mass.