Pseudocirrhosis

Discussion:

The patient had a history of metastatic breast cancer to the liver few years ago. Received chemotherapeutic treatment.

On follow up, there's complete resolution of the previously seen metastatic hepatic focal lesions. Instead, there's a reduced volume of the liver with irregular outline, capsular retraction and multiple linear bands of low attenuation traversing the hepatic parenchyma and reaching the hepatic surface, with some of them show linear calcifications.

The term "pseudocirrhosis" is intended to convey a different disease process compared with cirrhosis of chronic liver disease.

Two main factors correlates of pseudocirrhosis :

  • hepatic capsular retraction in response to chemotherapeutic agents, with nodular regenerative hyperplasia and absence of bridging fibrosis or cirrhosis on histopathology

  • extensive fibrosis representing a profound desmoplastic response to an infiltrating tumor, occurring prior to chemotherapy

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