Presentation
History of breast cancer metastatic to the liver and bones underwent mastectomy and received chemo and radiotherapeutic treatment. Now under follow up.
Patient Data
The liver is reduced in size showing irregular outline with capsular retraction and multiple linear fibrotic bands of low attenuation and delayed enhancement traversing the hepatic parenchyma and reaching to the hepatic surface. Some of the fibrotic linear bands show linear calcifications. Resolution of the previously seen metastatic hepatic focal lesions. No current hepatic focal lesions.
Case Discussion
The patient had a history of metastatic breast cancer to the liver few years ago. Received chemotherapeutic treatment.
On follow up, there's complete resolution of the previously seen metastatic hepatic focal lesions. Instead, there's a reduced volume of the liver with irregular outline, capsular retraction and multiple linear bands of low attenuation traversing the hepatic parenchyma and reaching the hepatic surface, with some of them show linear calcifications.
The term "pseudocirrhosis" is intended to convey a different disease process compared with cirrhosis of chronic liver disease.
Two main factors correlates of pseudocirrhosis :
hepatic capsular retraction in response to chemotherapeutic agents, with nodular regenerative hyperplasia and absence of bridging fibrosis or cirrhosis on histopathology
extensive fibrosis representing a profound desmoplastic response to an infiltrating tumor, occurring prior to chemotherapy
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