Acro-osteolysis

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Acro-osteolysis refers to resorption of the distal phalanx. The terminal tuft is most commonly affected but the shaft of the distal phalanx can also be affected in a few conditions. It is associated with a heterogeneous group of pathological entities and, some of which can be remembered by using the mnemonic PINCH FO.

Pathology

Multiple digits

Terminal tuft resorption

scleroderma ⁴
Raynaud disease
psoriatic arthritis
thermal injury
- extreme cold: frostbite
- extreme heat: burns, electricity
trauma
hyperparathyroidism
epidermolysis bullosa
porphyria
drugs
- phenytoin (occurs in infants of epileptic mothers treated with phenytoin) ⁷
- ergot poisoning/abuse
insensitivity to pain, e.g. leprosy
juvenile chronic arthritis
dermatomyositis
vascular occlusion ⁵
reactive arthritis ⁶
pityriasis rubra pilaris (very rare skin condition) ⁸

Midshaft resorption

polyvinyl chloride exposure
primary acro-osteolysis: Hajdu-Cheney syndrome
hyperparathyroidism (also causes terminal tuft resorption)

Single digit

-<p><strong>Acro-osteolysis</strong> refers to resorption of the <a href="/articles/distal-phalanx">distal phalanx</a>. The <a href="/articles/terminal-tuft">terminal tuft</a> is most commonly affected but the shaft of the distal phalanx can also be affected in a few conditions. It is associated with a heterogeneous group of pathological entities and, some of which can be remembered by using the mnemonic <a href="/articles/acro-osteolysis-mnemonic">PINCH FO</a>.</p><h4>Pathology</h4><h5>Multiple digits</h5><h6>Terminal tuft resorption</h6><ul>
+<p><strong>Acro-osteolysis</strong> refers to resorption of the distal phalanx. The <a href="/articles/terminal-tuft">terminal tuft</a> is most commonly affected but the shaft of the distal phalanx can also be affected in a few conditions. It is associated with a heterogeneous group of pathological entities and, some of which can be remembered by using the mnemonic <a href="/articles/acro-osteolysis-mnemonic">PINCH FO</a>.</p><h4>Pathology</h4><h5>Multiple digits</h5><h6>Terminal tuft resorption</h6><ul>
~~-<li><a title="Raynaud disease" href="/articles/raynaud-phenomenon">Raynaud disease</a></li>~~
+<li><a href="/articles/raynaud-phenomenon">Raynaud disease</a></li>

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