Adenosquamous carcinoma of endometrium (historical)
Updates to Article Attributes
Adenosquamous carcinoma of the endometrium is term formerly used to describe a rare histological subtype of endometrial cancer.
In general, it occurs in a slightly younger group when compared with pure adenocarcinoma of the endometrium4.
It that contains both malignant glandular and malignant squamous components. Adenosquamous
As of the 5th edition (2020) of the WHO classification of tumours of the uterine corpus, the subtype is no longer present. Instead, it is incorporated into the histological description for endometrioid carcinoma tendedof the endometrium as a villoglandular tumour that demonstrates squamous differentiation (which occurs in 10-25% of cases) 6.
It has previously been reported to beoccur in a slightly younger age group 4 with a slightly higher grade at presentation when compared to pure adenocarcinoma of the endometrium 2,5. However, the revised classification has moved away from the use of morphological features for prognostication, instead becoming increasingly reliant on molecular parameters such as POLE gene mutation status 6.
NB: adenosquamous carcinoma remains a histological subtype of cervical epithelial tumours.
-<p><strong>Adenosquamous carcinoma of the endometrium</strong> is a rare histological subtype of <a href="/articles/endometrial-carcinoma">endometrial cancer</a>. </p><p>In general, it occurs in a slightly younger group when compared with pure <a href="/articles/adenocarcinoma-endometrium">adenocarcinoma of the endometrium</a> <sup>4</sup>.</p><p>It contains both malignant glandular and malignant squamous components. Adenosquamous carcinoma tended to be slightly higher grade at presentation when compared to pure adenocarcinoma of the endometrium <sup>2,5</sup>.</p>- +<p><strong>Adenosquamous carcinoma of the endometrium</strong> is term formerly used to describe a rare histological subtype of <a href="/articles/endometrial-carcinoma">endometrial cancer</a> that contains both malignant glandular and malignant squamous components.</p><p>As of the 5<sup>th</sup> edition (2020) of the <a title="Malignant neoplasms involving the uterus" href="/articles/malignant-neoplasms-involving-the-uterus">WHO classification of tumours of the uterine corpus</a>, the subtype is no longer present. Instead, it is incorporated into the histological description for <a title="Endometrioid carcinoma of the endometrium" href="/articles/endometrioid-adenocarcinoma-of-the-endometrium">endometrioid carcinoma of the endometrium</a> as a villoglandular tumour that demonstrates squamous differentiation (which occurs in 10-25% of cases) <sup>6</sup>.</p><p>It has previously been reported to occur in a slightly younger age group <sup>4 </sup>with a slightly higher grade at presentation when compared to pure adenocarcinoma of the endometrium <sup>2,5</sup>. However, the revised classification has moved away from the use of morphological features for prognostication, instead becoming increasingly reliant on molecular parameters such as <em>POLE</em> gene mutation status <sup>6</sup>.</p><p>NB: <a title="Adenosquamous carcinoma (cervix)" href="/articles/adenosquamous-carcinoma-cervix">adenosquamous carcinoma</a> remains a histological subtype of <a title="WHO histological classification of tumours of the uterine cervix" href="/articles/who-histological-classification-of-tumours-of-the-uterine-cervix">cervical epithelial tumours</a>.</p>
References changed:
- 6. W. H. O. Classification WHO Classification of Tumours Editorial Board, Who Classification of Tumours Editorial. Female Genital Tumours: Who Classification of Tumours. (2020) ISBN: 9789283245049 - <a href="http://books.google.com/books?vid=ISBN9789283245049">Google Books</a>
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