Adenosquamous carcinoma of lung
Updates to Article Attributes
Adenosquamous carcinoma (ASC) of the lung is a rare type of non-small cell lung cancer.
Epidemiology
It is thought to constituting 0.4-4% of cases non-small cell lung cancer.
Risk factors
- cigarette smoking 8
Pathology
The definition of adenosquamous carcinoma indicates a carcinoma showing components of adenocarcinoma and squamous cell carcinoma, with each comprising at least 10% of the tumour 4.
Location
There may be a slight predominance towards the periphery of the lung 5-6.
Radiographic features
General
There appears to be a wide imaging spectrum both in terms of size and morphology 5. Differentiation from other histological forms on imaging grounds alone can be difficult. They usually present as a single lesion, with mean tumour size ranging from 2.8 to 3.8 cm (range 0.6-11 cm), based on two studies 5-6.
Treatment and prognosis
It is thought to be more aggressive than both pure adenocarcinoma of the lung and pure squamous cell carcinoma of the lung 1. Early stage disease may be amenable to surgery. There may also be an increased rate of lymph node metastases at the time of presentation compared with other histological types 7.
-<p><strong>Adenosquamous carcinoma (ASC) of the lung</strong> is a rare type of <a href="/articles/non-small-cell-lung-cancer">non-small cell lung cancer</a>.</p><h4>Epidemiology</h4><p>It is thought to constituting 0.4-4% of cases non-small cell lung cancer.</p><h4>Pathology</h4><p>The definition of adenosquamous carcinoma indicates a carcinoma showing components of adenocarcinoma and squamous cell carcinoma, with each comprising at least 10% of the tumour <sup>4</sup>.</p><h5>Location</h5><p>There may be a slight predominance towards the periphery of the lung <sup>5-6</sup>.</p><h4>Radiographic features</h4><h5>General</h5><p>There appears to be a wide imaging spectrum both in terms of size and morphology <sup>5</sup>. Differentiation from other histological forms on imaging grounds alone can be difficult. They usually present as a single lesion, with mean tumour size ranging from 2.8 to 3.8 cm (range 0.6-11 cm), based on two studies <sup>5-6</sup>.</p><h4>Treatment and prognosis</h4><p>It is thought to be more aggressive than both pure <a href="/articles/adenocarcinoma-of-the-lung">adenocarcinoma of the lung</a> and pure <a href="/articles/squamous-cell-carcinoma-of-the-lung">squamous cell carcinoma of the lung</a> <sup>1</sup>. Early stage disease may be amenable to surgery. There may also be an increased rate of lymph node metastases at the time of presentation compared with other histological types <sup>7</sup>. </p>- +<p><strong>Adenosquamous carcinoma (ASC) of the lung</strong> is a rare type of <a href="/articles/non-small-cell-lung-cancer-2">non-small cell lung cancer</a>.</p><h4>Epidemiology</h4><p>It is thought to constituting 0.4-4% of cases non-small cell lung cancer.</p><h5>Risk factors</h5><ul><li>cigarette smoking <sup>8</sup>
- +</li></ul><h4>Pathology</h4><p>The definition of adenosquamous carcinoma indicates a carcinoma showing components of adenocarcinoma and squamous cell carcinoma, with each comprising at least 10% of the tumour <sup>4</sup>.</p><h5>Location</h5><p>There may be a slight predominance towards the periphery of the lung <sup>5-6</sup>.</p><h4>Radiographic features</h4><h5>General</h5><p>There appears to be a wide imaging spectrum both in terms of size and morphology <sup>5</sup>. Differentiation from other histological forms on imaging grounds alone can be difficult. They usually present as a single lesion, with mean tumour size ranging from 2.8 to 3.8 cm (range 0.6-11 cm), based on two studies <sup>5-6</sup>.</p><h4>Treatment and prognosis</h4><p>It is thought to be more aggressive than both pure <a href="/articles/adenocarcinoma-of-the-lung">adenocarcinoma of the lung</a> and pure <a href="/articles/squamous-cell-carcinoma-of-the-lung">squamous cell carcinoma of the lung</a> <sup>1</sup>. Early stage disease may be amenable to surgery. There may also be an increased rate of lymph node metastases at the time of presentation compared with other histological types <sup>7</sup>. </p>
References changed:
- 8. Li C, Lu H. Adenosquamous carcinoma of the lung. (2018) OncoTargets and therapy. 11: 4829-4835. <a href="https://doi.org/10.2147/OTT.S164574">doi:10.2147/OTT.S164574</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/30147334">Pubmed</a> <span class="ref_v4"></span>
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