Amiodarone deposition in the liver
Updates to Article Attributes
Body
was changed:
Amiodarone hepatotoxicity is one of the complications that can occur with amiodarone therapy.
Clinical presentation
In the majority of patients, it is discovered incidentally during routine testing of liver biochemistry and rarely do the hepatic effects develop into symptomatic liver injury or failure 1-5.
Radiographic features
CT
While being non-specific, increased hepatic attenuation has been described as one of the effects of amiodarone on the liver 2,3. This however may not necessarily imply hepatotoxicity.
There is no published literature showing that dronedarone, a synthetic derivative of amiodarone, produces similar CT appearances. This is likely due to the absence of the iodine moieties in the dronedarone molecule. Nevertheless dronedarone can produce severe hepatotoxicity 6.
See also
-<p><strong>Amiodarone hepatotoxicity</strong> is one of the complications that can occur with amiodarone therapy. </p><h4>Clinical presentation</h4><p>In the majority of patients, it is discovered incidentally during routine testing of liver biochemistry and rarely do the hepatic effects develop into symptomatic liver injury or failure <sup>1-5</sup>. </p><h4>Radiographic features</h4><h5>CT </h5><p>While being non-specific, <a href="/articles/hepatic-attenuation-on-ct">increased hepatic attenuation</a> has been described as one of the effects of amiodarone on the liver <sup>2,3</sup>. This however may not necessarily imply hepatotoxicity.</p><p>There is no published literature showing that dronedarone, a synthetic derivative of amiodarone, produces similar CT appearances. This is likely due to the absence of the iodine moieties in the dronedarone molecule. Nevertheless dronedarone can produce severe hepatotoxicity <sup>6</sup>.</p><h4>See also</h4><ul><li><a href="/articles/amiodarone-lung-1">amiodarone lung</a></li></ul>- +<p><strong>Amiodarone hepatotoxicity</strong> is one of the complications that can occur with <a title="Amiodarone" href="/articles/amiodarone">amiodarone</a> therapy. </p><h4>Clinical presentation</h4><p>In the majority of patients, it is discovered incidentally during routine testing of liver biochemistry and rarely do the hepatic effects develop into symptomatic liver injury or failure <sup>1-5</sup>. </p><h4>Radiographic features</h4><h5>CT </h5><p>While being non-specific, <a href="/articles/hepatic-attenuation-on-ct">increased hepatic attenuation</a> has been described as one of the effects of amiodarone on the liver <sup>2,3</sup>. This however may not necessarily imply hepatotoxicity.</p><p>There is no published literature showing that dronedarone, a synthetic derivative of amiodarone, produces similar CT appearances. This is likely due to the absence of the iodine moieties in the dronedarone molecule. Nevertheless dronedarone can produce severe hepatotoxicity <sup>6</sup>.</p><h4>See also</h4><ul><li><a href="/articles/amiodarone-lung-1">amiodarone lung</a></li></ul>
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