Blueberry muffin syndrome (a.k.a. blueberry muffin baby or rash) refers to a skin appearance seen in pediatric patients with multiple raised cutaneous, classically blue/purple lesions which is due to extramedullary hematopoiesis in the dermis.
The syndrome was originally described in congenital rubella cases in the United States in the 1960s 3. It is also seen in other congenital infections, malignancies (e.g. primary adrenal neuroblastoma) and hematological disorders.
congenital vascular disease
- multiple hemangiomas of infancy
- multifocal lymphangioendotheliomatosis
- blue rubber bleb nevus syndrome
- multiple glomangiomas
- 1.van Ijsselmuiden MN, Bekhof J, Peek AM. A neonate with the 'blueberry muffin syndrome'. Ned Tijdschr Geneeskd. 2014;157 (33): A6460. Pubmed citation
- 2. Shaffer MP, Walling HW, Stone MS. Langerhans cell histiocytosis presenting as blueberry muffin baby. (2005) Journal of the American Academy of Dermatology. 53 (2 Suppl 1): S143-6. doi:10.1016/j.jaad.2005.01.015 - Pubmed
- 3. Mehta V, Balachandran C, Lonikar V. Blueberry muffin baby: a pictoral differential diagnosis. (2008) Dermatology online journal. 14 (2): 8. Pubmed