Cardiac blood pool scan
Updates to Article Attributes
Body
was changed:
EquilibriumA multi-gated (MUGA) cardiac blood scan scan is a common study
performed in patients who are receiving potentially cardiotoxic chemotherapy. Indications
- acute myocardial infarction (AMI)
- coronary artery disease (CAD)
- evaluation after coronary artery bypass graft surgery
- cardiomyopathy / myocarditis
- assessment of drug therapy
-
pulmonary disease
- RV enlargement
- cor pulmonale
- normal LV ejection fraction, wall motion and chamber size strongly suggests a pulmonary aeitiology
Blood pool agent
- Tc labelled RBC
Technique
- patient in normal sinus rhythm
- IV administration of Tc Labelled RBC
- ECG gated – with R wave gating
- minimum of 16 frames/cardiac cycle
- at rest and exercise
First pass study
This is obtained by injecting a compact bolus of suitable radiopharmaceutical intravenously.
- major advantage: data collected rapidly over very few cardiac cycles allows measurement of ventricular function at peak stress during exercise ventriculography
- major disadvantage: counting statistics are low and only a limited number of views are possible
Analysis
- qualitative analysis
- quantitative analysis
- functional parameters
- wall motion assessment (regional and global)
- ED and ES ventricular volume
- stroke volume
- cardiac output
- ejection fraction ( LV and RV)
- regurgitant fraction (stroke index ratio)
- ventricular filling and emptying rates
- cardiac shunt quantitation
- left to right shunts – evaluated using the first transit technique (NOT equilibrium)
- right to left shunts – evaluated using Tc99m labelled macro-aggregated albumin and comparing ratio of tracer in the lung to tracer gaining access to the systemic circulation
Clinical settings for assessment
acute myocardial infarction (AMI)coronary artery disease (CAD)evaluation after coronary artery bypass graft surgerycardiomyopathy / myocarditisassessment of drug therapy-
pulmonary diseaseRV enlargementcor pulmonalenormal LV ejection fraction, wall motion and chamber size strongly suggests a pulmonary aeitiology
First pass study
This is obtained by injecting a compact bolus of suitable radiopharmaceutical intravenously.
major advantage : data collected rapidly over very few cardiac cycles allows measurement of ventricular function at peak stress during exercise ventriculography
major disadvantage : counting statistics are low and only a limited number of views are possible
-<a name="Equilibrium_study"></a><h4> <span> Equilibrium study </span>-</h4><a name="Blood_pool_agent:"></a><h4> <span> Blood pool agent</span>-</h4><p>Tc labelled RBC-</p><a name="Technique:"></a><h4> <span> Technique</span>-</h4><ul>-<li>patient in normal sinus rhythm-</li>-<li> IV administration of Tc Labelled RBC-</li>-<li> ECG gated – with R wave gating-</li>-<li>minimum of 16 frames/cardiac cycle-</li>-<li>at rest and exercise-</li>-</ul><a name="Analysis:"></a><h4> <span> Analysis</span>-</h4><ul>-<li>qualitative analysis-</li>-<li>quantitative analysis-</li>-<li>functional parameters<ul>-<li>wall motion assessment (regional and global)-</li>-<li> ED and ES ventricular volume-</li>-<li>stroke volume-</li>-<li>cardiac output-</li>-<li>ejection fraction ( LV and RV)-</li>-<li>regurgitant fraction (stroke index ratio)-</li>-<li>ventricular filling and emptying rates-</li>-<li>cardiac shunt quantitation-<ul>-<li>left to right shunts – evaluated using the first transit technique (NOT equilibrium)-</li>-<li>right to left shunts – evaluated using Tc99m labelled macro-aggregated albumin and comparing ratio of tracer in the lung to tracer gaining access to the systemic circulation-</li>- +<p>A multi-gated (MUGA) <strong>cardiac blood scan scan</strong> is a common study performed in patients who are receiving potentially cardiotoxic chemotherapy. </p><h4>Indications</h4><ul>
- +<li>acute myocardial infarction (AMI)</li>
- +<li>coronary artery disease (CAD)</li>
- +<li>evaluation after coronary artery bypass graft surgery</li>
- +<li>cardiomyopathy / myocarditis</li>
- +<li>assessment of drug therapy</li>
- +<li>pulmonary disease<ul>
- +<li>RV enlargement</li>
- +<li>cor pulmonale</li>
- +<li>normal LV ejection fraction, wall motion and chamber size strongly suggests a pulmonary aeitiology</li>
-</li>- +</li>
- +</ul><h4>Tracer dose and route of administration</h4><ul><li>Tc labelled RBC</li></ul><h4>Technique</h4><ul>
- +<li>patient in normal sinus rhythm</li>
- +<li>IV administration of Tc Labelled RBC</li>
- +<li>ECG gated – with R wave gating</li>
- +<li>minimum of 16 frames/cardiac cycle</li>
- +<li>at rest and exercise</li>
- +</ul><h5>First pass study</h5><p>This is obtained by injecting a compact bolus of suitable radiopharmaceutical intravenously.</p><ul><li>major advantage: data collected rapidly over very few cardiac cycles allows measurement of ventricular function at peak stress during exercise ventriculography</li></ul><ul><li>major disadvantage: counting statistics are low and only a limited number of views are possible</li></ul><h4>Analysis</h4><ul>
- +<li>qualitative analysis</li>
- +<li>quantitative analysis</li>
- +<li>functional parameters<ul>
- +<li>wall motion assessment (regional and global)</li>
- +<li>ED and ES ventricular volume</li>
- +<li>stroke volume</li>
- +<li>cardiac output</li>
- +<li>ejection fraction ( LV and RV)</li>
- +<li>regurgitant fraction (stroke index ratio)</li>
- +<li>ventricular filling and emptying rates</li>
- +<li>cardiac shunt quantitation<ul>
- +<li>left to right shunts – evaluated using the first transit technique (NOT equilibrium)</li>
- +<li>right to left shunts – evaluated using Tc99m labelled macro-aggregated albumin and comparing ratio of tracer in the lung to tracer gaining access to the systemic circulation</li>
-</li>-</ul><a name="Clinical_settings_for_assessment:"></a><h4> <span> Clinical settings for assessment</span>-</h4><ul>-<li>acute myocardial infarction (AMI)</li>-<li>coronary artery disease (CAD)</li>-<li>evaluation after coronary artery bypass graft surgery-</li>-<li>cardiomyopathy / myocarditis-</li>-<li>assessment of drug therapy-</li>-<li>pulmonary disease-<ul>-<li>RV enlargement-</li>-<li>cor pulmonale-</li>-<li>normal LV ejection fraction, wall motion and chamber size strongly suggests a pulmonary aeitiology-</li>- +</li>
-</li>-</ul><a name="First_pass_study"></a><h2> <span> First pass study </span>-</h2><p>This is obtained by injecting a compact bolus of suitable radiopharmaceutical intravenously.-</p><ul><li>major advantage : data collected rapidly over very few cardiac cycles allows measurement of ventricular function at peak stress during exercise ventriculography-</li></ul><ul><li>major disadvantage : counting statistics are low and only a limited number of views are possible-</li></ul>- +</li>
- +</ul>
References changed:
- 1. Hong WK, Jr. RCB, Hait WN et-al. Holland-Frei Cancer Medicine, 8/e. pmph usa. ISBN:1607950146. <a href="http://books.google.com/books?vid=ISBN1607950146">Read it at Google Books</a> - <a href="http://www.amazon.com/gp/product/1607950146">Find it at Amazon</a><span class="auto"></span>
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