Classification of ductal carcinoma in situ (DCIS)
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The new pathological classification of DCIS is based on cytonuclear atypia, degree of necrosis, size, and distance from margin/architecture. Low and intermediate grades DCIS require cytologic, architectural and size criteria to be met but high-grade DCIS requires only cytologic criteria; this is as follows:
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Lowlow grade- round, regular to mildly irregular nuclei up to 2-3 times the size of a red blood cell
- no comedo necrosis
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Intermediateintermediate grade- round, regular to mildly irregular nuclei up to 2-3 times the size of a red blood cell
- substantial comedo necrosis
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Highhigh grade- pleomorphic nuclei more than 3 times the size of a red blood cell
- substantial comedo necrosis usually present, but not required for the diagnosis
-<p>The new pathological classification of <a title="Ductal carcinoma in situ (DCIS)" href="/articles/ductal-carcinoma-in-situ">DCIS </a>is based on cytonuclear atypia, degree of necrosis, size, and distance from margin/architecture. Low and intermediate grades DCIS require cytologic, architectural and size criteria to be met but high-grade DCIS requires only cytologic criteria; this is as follows:</p><p><strong>Low grade</strong></p><ul>- +<p>The new <strong>pathological classification of </strong><a href="/articles/ductal-carcinoma-in-situ"><strong>DCIS</strong> </a>is based on cytonuclear atypia, degree of necrosis, size, and distance from margin/architecture. Low and intermediate grades DCIS require cytologic, architectural and size criteria to be met but high-grade DCIS requires only cytologic criteria; this is as follows:</p><ul>
- +<li>
- +<strong>low grade</strong><ul>
-</ul><p><strong>Intermediate grade</strong></p><ul>- +</ul>
- +</li>
- +<li>
- +<strong>intermediate grade</strong><ul>
-</ul><p><strong>High grade</strong></p><ul>- +</ul>
- +</li>
- +<li>
- +<strong>high grade</strong><ul>
- +</ul>
- +</li>
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