Diffuse cerebellar atrophy
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Diffuse atrophy of the cerebellum refers to degeneration/reduction from a previously normal cerebellar volume.
Terminology
Cerebellar atrophy slightly differs from cerebellar hypoplasia meaning the cerebellum was not well formed to start with.
Pathology
Aetiology
Diffuse atrophy can result from a variety of causes:
- normal ageing
- alcoholic cerebellar degeneration
- drugs, e.g. phenytoin cerebellar degeneration
- chronic temporal lobe epilepsy (independently from phenytoin use) 7
- cerebellitis
- multisystem atrophy (MSA) 4
- superficial siderosis 8
- ataxia telangiectasia
- Friedreich ataxia
- Fahr disease: atrophy not specific to cerebellum
- paraneoplastic cerebellar degeneration (PCD)
- olivopontocerebellar atrophy (OPCA) 6
- cerebrotendinous xanthomatosis
- Marinesco-Sjögrensyndrome (MSS) 5
Differential diagnosis
-<li>drugs, e.g. <a title="phenytoin cerebellar degeneration" href="/articles/phenytoin-cerebellar-degeneration">phenytoin cerebellar degeneration</a>- +<li>drugs, e.g. <a href="/articles/phenytoin-cerebellar-degeneration">phenytoin cerebellar degeneration</a>
-<li><a href="/articles/paraneoplastic-cerebellar-degeneration-pcd">paraneoplastic cerebellar degeneration (PCD)</a></li>- +<li><a title="Paraneoplastic cerebellar degeneration" href="/articles/paraneoplastic-cerebellar-degeneration">paraneoplastic cerebellar degeneration (PCD)</a></li>
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