Disappearing basal ganglia sign
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- updated 11 May 2022:
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The disappearing basal ganglia sign is one of the early signs of a middle cerebral artery (MCA) infarction. It is defined as the loss of delineation of the basal ganglia, due to blurring of their grey-white matter interface and hypoattenuation, consequent to cytotoxic oedema at the time of an ischaemic event.
It is best appreciated when compared to the contralateral side.
Other associated early signs of MCA infarction are:
- loss of the insular ribbon sign
- obscuration of the lentiform nucleus
- hyperdense MCA sign
-<p>The <strong>disappearing basal ganglia sign</strong> is one of the early signs of a <a title="MCA infarction" href="/articles/middle-cerebral-artery-mca-infarct">middle cerebral artery (MCA) infarction</a>. It is defined as the loss of delineation of the basal ganglia, due to blurring of their grey-white matter interface and hypoattenuation, consequent to <a href="/articles/cytotoxic-cerebral-oedema">cytotoxic oedema</a> at the time of an ischaemic event.</p><p>It is best appreciated when compared to the contralateral side.</p><p>Other associated early signs of MCA infarction are:</p><ul>-<li><a href="/articles/loss-of-the-insular-ribbon-sign">loss of the insular ribbon sign</a></li>-<li>obscuration of the lentiform nucleus</li>-<li><a href="/articles/hyperdense-mca-sign-brain">hyperdense MCA sign</a></li>- +<p>The <strong>disappearing basal ganglia sign</strong> is one of the early signs of a <a title="MCA infarction" href="/articles/middle-cerebral-artery-mca-infarct">middle cerebral artery (MCA) infarction</a>. It is defined as the loss of delineation of the basal ganglia, due to blurring of their grey-white matter interface and hypoattenuation, consequent to <a href="/articles/cytotoxic-cerebral-oedema">cytotoxic oedema</a> at the time of an ischaemic event.</p><p>It is best appreciated when compared to the contralateral side.</p><p>Other associated early signs of MCA infarction are:</p><ul>
- +<li><a href="/articles/loss-of-the-insular-ribbon-sign">loss of the insular ribbon sign</a></li>
- +<li>obscuration of the lentiform nucleus</li>
- +<li><a href="/articles/hyperdense-mca-sign-brain-1">hyperdense MCA sign</a></li>
References changed:
- 1. Saenz R. The Disappearing Basal Ganglia Sign. Radiology. 2005;234(1):242-3. <a href="https://doi.org/10.1148/radiol.2341030252">doi:10.1148/radiol.2341030252</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/15618384">Pubmed</a>
- 2. Nakano S, Iseda T, Kawano H, Yoneyama T, Ikeda T, Wakisaka S. Correlation of Early CT Signs in the Deep Middle Cerebral Artery Territories with Angiographically Confirmed Site of Arterial Occlusion. AJNR Am J Neuroradiol. 2001;22(4):654-9. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976034">PMC7976034</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/11290473">Pubmed</a>
- 3. Truwit C, Barkovich A, Gean-Marton A, Hibri N, Norman D. Loss of the Insular Ribbon: Another Early CT Sign of Acute Middle Cerebral Artery Infarction. Radiology. 1990;176(3):801-6. <a href="https://doi.org/10.1148/radiology.176.3.2389039">doi:10.1148/radiology.176.3.2389039</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/2389039">Pubmed</a>
- 1.Saenz RC. The disappearing basal ganglia sign. Radiology. 2005;234 (1): 242-3. Radiology (full text) - doi:10.1148/radiol.2341030252 - Pubmed citation
- 3.Nakano S, Iseda T, Kawano H et-al. Correlation of early CT signs in the deep middle cerebral artery territories with angiographically confirmed site of arterial occlusion. AJNR Am J Neuroradiol. 2001;22 (4): 654-9. AJNR Am J Neuroradiol (full text) - Pubmed citation
- 4.Truwit CL, Barkovich AJ, Gean-Marton A et-al. Loss of the insular ribbon: another early CT sign of acute middle cerebral artery infarction. Radiology. 1990;176 (3): 801-6. Radiology (abstract) - Pubmed citation