Disseminated intravascular coagulation
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Disseminated intravascular coagulation (DIC(DIC), also known as consumption coagulopathy and defibrination syndrome, refers to a systemic phenomenon of overactivation of coagulation and fibrinolysis.
Clinical presentation
Patients present with bleeding and/or thrombosis, as well as organ-specific sequelae of these processes.
Pathology
Aetiology
The most common causes of this condition are infection, malignancy, and trauma (including surgery) 1,2.
Markers
The diagnosis is supported by laboratory findings of coagulopathy and/or fibrinolysis. These include low platelets, low fibrinogen, elevated D-dimer, prolonged prothrombin time (PT), prolonged international normalized ratio (INR), and prolonged activated partial thromboplastin time (aPTT).
-<p><strong>Disseminated intravascular coagulation </strong>(DIC), also known as <strong>consumption coagulopathy and defibrination syndrome</strong>, refers to a systemic phenomenon of overactivation of coagulation and fibrinolysis.</p><h4>Clinical presentation</h4><p>Patients present with bleeding and/or thrombosis, as well as organ-specific sequelae of these processes.</p><h4>Pathology</h4><h5>Aetiology</h5><p>The most common causes of this condition are infection, malignancy, and trauma (including surgery) <sup>1,2</sup>.</p><h5>Markers</h5><p>The diagnosis is supported by laboratory findings of coagulopathy and/or fibrinolysis. These include low platelets, low fibrinogen, elevated D-dimer, prolonged prothrombin time (PT), prolonged international normalized ratio (INR), and prolonged activated partial thromboplastin time (aPTT).</p>- +<p><strong>Disseminated intravascular coagulation </strong>(<strong>DIC</strong>), also known as <strong>consumption coagulopathy and defibrination syndrome</strong>, refers to a systemic phenomenon of overactivation of coagulation and fibrinolysis.</p><h4>Clinical presentation</h4><p>Patients present with bleeding and/or thrombosis, as well as organ-specific <a title="Sequelae" href="/articles/sequela">sequelae</a> of these processes.</p><h4>Pathology</h4><h5>Aetiology</h5><p>The most common causes of this condition are infection, malignancy, and trauma (including surgery) <sup>1,2</sup>.</p><h5>Markers</h5><p>The diagnosis is supported by laboratory findings of coagulopathy and/or fibrinolysis. These include low platelets, low fibrinogen, <a title="D-dimer" href="/articles/d-dimer-1">elevated D-dimer</a>, prolonged prothrombin time (PT), prolonged international normalized ratio (INR), and prolonged activated partial thromboplastin time (aPTT).</p>
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