Drug rash with eosinophilia and systemic symptoms syndrome
Updates to Article Attributes
Drug rash with eosinophilia and systemic symptoms (DRESS) is a syndrome reflects reflecting a marked hypersensitivity reaction to drugs or medications.
Clinical presentation
Clinical presentation can be variable and symptoms may arise from 2 to 8 weeks after initiating the offending drug. Typical clinical features include skin rash, fever, lymph node enlargement, and internal organ involvement. In terms of internal organ involvement, it most commonly involves the liver followed by the kidneys and lungs.
Pathology
The pathophysiology of DRESS syndrome is not well known. Many drug have been be known to cause precipitation of this syndrome and includes
- anticonvulsants
- sulfonamides
- dapsone
- allopurinol
- minocycline
- gold salts
Serology
- serum eosinophils are often elevated 5
Radiographic features
Lung involvement
CT
CT chest is often non-specific but may be represented by diffuse multifocal infiltrative opacification 5.
Treatment and prognosis
The prognosis can be variable but can carry a mortality of up to ~10% in patients with multi-organ involvement. Withdrawal of the causative drug and steroid therapy as traditionally been a mainstay of treatment.
History and etymology
It was first described in 1996 by Bocquet et al 1.
-<p><strong>Drug rash with eosinophilia and systemic symptoms (DRESS) </strong>is a syndrome reflects a marked hypersensitivity reaction to drugs or medications.</p><h4>Clinical presentation </h4><p>Clinical presentation can be variable and symptoms may arise from 2 to 8 weeks after initiating the offending drug. Typical clinical features include skin rash, fever, lymph node enlargement, and internal organ involvement. In terms of internal organ involvement, it most commonly involves the liver followed by the kidneys and lungs.</p><h4>Pathology</h4><p>The pathophysiology of DRESS syndrome is not well known. Many drug have been be known to cause precipitation of this syndrome and includes</p><ul>- +<p><strong>Drug rash with eosinophilia and systemic symptoms (DRESS) </strong>is a syndrome reflecting a marked hypersensitivity reaction to drugs or medications.</p><h4>Clinical presentation </h4><p>Clinical presentation can be variable and symptoms may arise from 2 to 8 weeks after initiating the offending drug. Typical clinical features include skin rash, fever, lymph node enlargement, and internal organ involvement. In terms of internal organ involvement, it most commonly involves the liver followed by the kidneys and lungs.</p><h4>Pathology</h4><p>The pathophysiology of DRESS syndrome is not well known. Many drug have been be known to cause precipitation of this syndrome and includes</p><ul>
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