Ears of the lynx sign (brain)
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The ears of the lynx sign refers to abnormal T2/FLAIR cone-shaped hyperintensity at the tip of the frontal horn of the lateral ventricles in the region of forceps minor which resembles the tufts of hair crowning the ears of a lynx.
This sign is seen in hereditary spastic paraplegia associated with thin corpus callosum (HSP-TCC), a form of hereditary spastic paraplegia associated with mutations of the spastic paraparesis gene 11 (SPG11) on chromosome 15 1,2. It is a characteristic early imaging finding of hereditary spastic paraplegia with thin corpus callosum (HSP-TCC). The spatacsin vesicle trafficking associated (SPG11) gene, codes spatacsin. The sign may also be seen in SPG15, which is caused by mutation in zinc finger fyve domain-containing protein 26(ZFYVE26) gene, encoding spastizin. This sign has also been described in Marchiafava-Bignami disease 3.
-<p>The <strong>ears of the lynx sign</strong> refers to abnormal T2/FLAIR cone-shaped hyperintensity at the tip of the frontal horn of the lateral ventricles in the region of forceps minor which resembles the tufts of hair crowning the ears of a lynx. This sign is seen in <a href="/articles/hereditary-spastic-paraplegia">hereditary spastic paraplegia</a> associated with mutations of the spastic paraparesis gene 11 (SPG11) on chromosome 15 <sup>1,2</sup>. It is a characteristic early imaging finding of hereditary spastic paraplegia with thin corpus callosum (HSP-TCC). The <em>spatacsin vesicle trafficking associated</em> (SPG11) gene, codes spatacsin. The sign may also be seen in SPG15, which is caused by mutation in <em>zinc finger fyve domain-containing protein 26</em>, encoding spastizin. This sign has also been described in <a href="/articles/marchiafava-bignami-disease-1">Marchiafava-Bignami disease</a> <sup>3</sup>.</p>- +<p>The <strong>ears of the lynx sign</strong> refers to abnormal T2/FLAIR cone-shaped hyperintensity at the tip of the frontal horn of the lateral ventricles in the region of forceps minor which resembles the tufts of hair crowning the ears of a lynx.</p><p>This sign is seen in <a href="/articles/hereditary-spastic-paraplegia">hereditary spastic paraplegia</a> with thin corpus callosum (HSP-TCC), a form of hereditary spastic paraplegia associated with mutations of the spastic paraparesis gene 11 (SPG11) on chromosome 15 <sup>1,2</sup>. The <em>spatacsin vesicle trafficking associated</em> (SPG11) gene, codes spatacsin. The sign may also be seen in SPG15, which is caused by mutation in <em>zinc finger fyve domain-containing protein 26 </em>(<em>ZFYVE26</em>) gene, encoding spastizin. This sign has also been described in <a href="/articles/marchiafava-bignami-disease-1">Marchiafava-Bignami disease</a> <sup>3</sup>.</p>
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