Extramedullary hematopoiesis in the adrenal gland
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Extramedullary hematopoiesishaematopoiesis (EMH) is in the adrenal gland is a rare physiologic compensatory event in many hematologichaematologic diseases. It
Epidemiology
Extramedullar haematopoiesis in the adrenal gland is uncommon 2. Instead, it occurs most commonly in the spleen, liver, and lymph nodes and less frequently in the lung, pleura, breast, thymus, small bowel, and central nervous system.1.
Pathology
EMH in theThe adrenal is uncommon,2 There are few reports on EMH in the adrenal gland in patients with thalassemia 3
Adrenal glandglands might be involved unilaterally or bilaterally 4. Although rare, there are few reports describing extramedullar haematopoiesis in the adrenal gland in patients with thalassaemia 3.
The exact mechanism of EMHextramedullar haematopoiesis in the adrenal gland is unknown. Several hypotheses include:5:
- adrenal gland has
hematopoietichaematopoietic capacity during the fetal period andEMHextramedullar haematopoiesis may develop from primitive rests in diseased condition -
other theories suggest embolizationembolisation of hematopoietic stem cells in adrenal gland may occur. Chronic -
there may be chronic hypoxia
is another presumptive cause4,6
-<p><a href="/articles/extramedullary-haematopoiesis">Extramedullary hematopoiesis</a> (EMH) is a physiologic compensatory event in many hematologic diseases. It occurs most commonly in the spleen, liver, and lymph nodes and less frequently in the lung, pleura, breast, thymus, small bowel, and central nervous system.<sup>1</sup></p><p> EMH in the adrenal is uncommon,<sup>2</sup> There are few reports on EMH in the adrenal gland in patients with thalassemia <sup>3</sup> </p><p>Adrenal gland might be involved unilaterally or bilaterally <sup>4</sup> </p><p>The exact mechanism of EMH in the adrenal gland is unknown. Several hypotheses include:<sup>5</sup></p><ul>-<li>adrenal gland has hematopoietic capacity during the fetal period and EMH may develop from primitive rests in diseased condition</li>-<li>other theories suggest embolization of hematopoietic stem cells in adrenal gland may occur. Chronic hypoxia is another presumptive cause<sup> 4,6 </sup>- +<p><strong><a href="/articles/extramedullary-haematopoiesis">Extramedullary haematopoiesis</a> in the adrenal gland</strong> is a rare physiologic compensatory event in many haematologic diseases.</p><h4>Epidemiology</h4><p>Extramedullar haematopoiesis in the <a title="Adrenal gland" href="/articles/adrenal-gland">adrenal gland</a> is uncommon <sup>2</sup>. Instead, it occurs most commonly in the spleen, liver, and lymph nodes and less frequently in the lung, pleura, breast, thymus, small bowel, and central nervous system <sup>1</sup>.</p><h4>Pathology</h4><p>The adrenal glands might be involved unilaterally or bilaterally <sup>4</sup>. Although rare, there are few reports describing extramedullar haematopoiesis in the adrenal gland in patients with <a title="Thalassaemia" href="/articles/thalassaemia">thalassaemia</a> <sup>3</sup>.</p><p>The exact mechanism of extramedullar haematopoiesis in the adrenal gland is unknown. Several hypotheses include <sup>5</sup>:</p><ul>
- +<li>adrenal gland has haematopoietic capacity during the fetal period and extramedullar haematopoiesis may develop from primitive rests in diseased condition</li>
- +<li>embolisation of hematopoietic stem cells in adrenal gland may occur</li>
- +<li>there may be chronic hypoxia <sup>4,6 </sup>
Tags changed:
- re-write
Systems changed:
- Haematology
- Gastrointestinal
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