Eye of the tiger sign (globus pallidus)
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The eye of the tiger sign refers to abnormal low T2 signal on MRI (due to abnormal accumulation of iron) in the globus pallidus with a longitudinal stripe of high signal (due to gliosis and spongiosis).
The eye of the tiger sign is most classically associated with Pantothenatepantothenate kinase-associated neurodegeneration1,2,3-3 although it is not pathognomonic.5. There are no formalizedformalised criteria for the sign6, and other conditions may demonstrate a similar appearance, such as Wilson disease7, atypical parkinsonism8, and organophosphate poisoning9; it may also be a normal finding on a 3 Teslatesla magnet6, Therefore. Therefore, caution should be used when interpreting this sign.
-<p>The <strong>eye of the tiger sign</strong> refers to abnormal low T2 signal on MRI (due to abnormal accumulation of iron) in the <a href="/articles/globus-pallidus">globus pallidus</a> with a longitudinal stripe of high signal (due to gliosis and spongiosis). </p><p>The eye of the tiger sign is most classically associated with <a href="/articles/pantothenate-kinase-associated-neurodegeneration">Pantothenate kinase-associated neurodegeneration</a><sup>1,2,3 </sup>although it is not pathognomonic.<sup>5</sup> There are no formalized criteria for the sign<sup>6</sup>, and other conditions may demonstrate a similar appearance, such as Wilson disease<sup>7</sup>, atypical parkinsonism<sup>8</sup>, and organophosphate poisoning<sup>9</sup>; it may also be a normal finding on a 3 Tesla magnet<sup>6</sup>, Therefore, caution should be used when interpreting this sign.</p>- +<p>The <strong>eye of the tiger sign</strong> refers to abnormal low T2 signal on MRI (due to abnormal accumulation of iron) in the <a href="/articles/globus-pallidus">globus pallidus</a> with a longitudinal stripe of high signal (due to gliosis and spongiosis). </p><p>The eye of the tiger sign is most classically associated with <a href="/articles/pantothenate-kinase-associated-neurodegeneration">pantothenate kinase-associated neurodegeneration</a> <sup>1-3 </sup>although it is not pathognomonic <sup>5</sup>. There are no formalised criteria for the sign <sup>6</sup>, and other conditions may demonstrate a similar appearance, such as Wilson disease <sup>7</sup>, atypical parkinsonism <sup>8</sup>, and organophosphate poisoning <sup>9</sup>; it may also be a normal finding on a 3 tesla magnet <sup>6</sup>. Therefore, caution should be used when interpreting this sign.</p>
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- 2. Angelini L, Nardocci N, Rumi V et al. Hallervorden-Spatz disease: clinical and MRI study of 11 cases diagnosed in life. J. Neurol. 1992;239 (8): 417-25. - <a href="http://www.ncbi.nlm.nih.gov/pubmed/1447570">Pubmed citation</a><div class="ref_v2"></div>
- 3. Savoiardo M, Halliday WC, Nardocci N et al. Hallervorden-Spatz disease: MR and pathologic findings. AJNR Am J Neuroradiol. 1993; 14 (1): 155-62. <a href="http://www.ajnr.org/cgi/content/citation/14/1/155">AJNR Am J Neuroradiol (citation)</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/8427079">Pubmed citation</a><div class="ref_v2"></div>
- 2. Angelini L, Nardocci N, Rumi V et-al. Hallervorden-Spatz disease: clinical and MRI study of 11 cases diagnosed in life. J. Neurol. 1992;239 (8): 417-25. - <a href="http://www.ncbi.nlm.nih.gov/pubmed/1447570">Pubmed citation</a><div class="ref_v2"></div>
- 3. Savoiardo M, Halliday WC, Nardocci N et-al. Hallervorden-Spatz disease: MR and pathologic findings. AJNR Am J Neuroradiol. 1993; 14 (1): 155-62. <a href="http://www.ajnr.org/cgi/content/citation/14/1/155">AJNR Am J Neuroradiol (citation)</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/8427079">Pubmed citation</a><div class="ref_v2"></div>
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