Eye of the tiger sign (globus pallidus)
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The eye of the tiger sign refers to abnormal low T2 signal on MRI (due to abnormal accumulation of iron) in the globus pallidus with a longitudinal stripe of high signal (due to gliosis and spongiosis).
The eye of the tiger sign is most classically associated with pantothenate kinase-associated neurodegeneration 1-3 although it is not pathognomonic 5. There are no formalised criteria for the sign 6, and other conditions may demonstrate a similar appearance, such as Wilson disease 7, atypical parkinsonism 8, and organophosphate poisoning 9; it may also be a normal finding on a 3 tesla magnet 6. Therefore, caution should be used when interpreting this sign.
-<p>The <strong>eye of the tiger sign</strong> refers to abnormal low T2 signal on MRI (due to abnormal accumulation of iron) in the <a href="/articles/globus-pallidus">globus pallidus</a> with a longitudinal stripe of high signal (due to gliosis and spongiosis). </p><p>The eye of the tiger sign is most classically associated with <a href="/articles/pantothenate-kinase-associated-neurodegeneration">pantothenate kinase-associated neurodegeneration</a> <sup>1-3 </sup>although it is not pathognomonic <sup>5</sup>. There are no formalised criteria for the sign <sup>6</sup>, and other conditions may demonstrate a similar appearance, such as Wilson disease <sup>7</sup>, atypical parkinsonism <sup>8</sup>, and organophosphate poisoning <sup>9</sup>; it may also be a normal finding on a 3 tesla magnet <sup>6</sup>. Therefore, caution should be used when interpreting this sign.</p>- +<p>The <strong>eye of the tiger sign</strong> refers to abnormal low T2 signal on MRI (due to abnormal accumulation of iron) in the <a href="/articles/globus-pallidus">globus pallidus</a> with a longitudinal stripe of high signal (due to gliosis and spongiosis). </p><p>The eye of the tiger sign is most classically associated with <a href="/articles/pantothenate-kinase-associated-neurodegeneration">pantothenate kinase-associated neurodegeneration</a> <sup>1-3 </sup>although it is not pathognomonic <sup>5</sup>. There are no formalised criteria for the sign <sup>6</sup>, and other conditions may demonstrate a similar appearance, such as <a href="/articles/wilson-disease">Wilson disease</a> <sup>7</sup>, atypical parkinsonism <sup>8</sup>, and <a href="/articles/organophosphate-poisoning">organophosphate poisoning</a> <sup>9</sup>; it may also be a normal finding on a 3 tesla magnet <sup>6</sup>. Therefore, caution should be used when interpreting this sign.</p>
References changed:
- 9. Srinivasan KG, Praveen KM, Ushanandhini KP, Ramprabananth S. MRI Eye-of-the-Tiger Sign in Organophosphate Poisoning. A Case Report. (2010) The neuroradiology journal. 23 (4): 407-11. <a href="https://doi.org/10.1177/197140091002300405">doi:10.1177/197140091002300405</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/24148628">Pubmed</a> <span class="ref_v4"></span>
- 9. Srinivasan KG, M Praveen Kumar, KP Ushanandhini and S Ramprabananth. MRI Eye-of-the-Tiger Sign in Organophosphate Poisoning. A Case Report. Neuroradiol J. 2010;23 (4): 407–11. <a href="https://doi.org/10.1177/197140091002300405" target="_blank">. doi:10.1177/197140091002300405</a>.
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