Eye of the tiger sign (globus pallidus)
Updates to Article Attributes
Body
was changed:
The eye of the tiger sign refers to symmetric bilateral abnormal low T2 signal on T2-weighted MRI (due to abnormal accumulation of iron) in the globus pallidus with a longitudinal stripe ofcentral high signal (due to gliosis and spongiosis).
The eye of the tiger sign is most classically associated with pantothenate kinase-associated neurodegeneration 1-3 although it is not pathognomonic particularly in adults 5. There are no formalised criteria for the sign 6 and other conditions may demonstrate a similar appearance, such as Wilson disease 7, atypical parkinsonism 8 and organophosphate poisoning 9; it may also be a normal finding on a 3 T magnet 6. Therefore, caution should be used when interpreting this sign.
-<p>The <strong>eye of the tiger sign</strong> refers to abnormal low T2 signal on MRI (due to abnormal accumulation of iron) in the <a href="/articles/globus-pallidus">globus pallidus</a> with a longitudinal stripe of high signal (due to gliosis and spongiosis). </p><p>The eye of the tiger sign is most classically associated with <a href="/articles/pantothenate-kinase-associated-neurodegeneration">pantothenate kinase-associated neurodegeneration</a> <sup>1-3 </sup>although it is not pathognomonic <sup>5</sup>. There are no formalised criteria for the sign <sup>6 </sup>and other conditions may demonstrate a similar appearance, such as <a href="/articles/wilson-disease-2">Wilson disease</a> <sup>7</sup>, atypical parkinsonism <sup>8 </sup>and <a href="/articles/organophosphate-poisoning">organophosphate poisoning</a> <sup>9</sup>; it may also be a normal finding on a 3 T magnet <sup>6</sup>. Therefore, caution should be used when interpreting this sign.</p>- +<p>The <strong>eye of the tiger sign</strong> refers to symmetric bilateral abnormal low signal on T2-weighted MRI (due to abnormal accumulation of iron) in the <a href="/articles/globus-pallidus">globus pallidus</a> with central high signal (due to gliosis and spongiosis).</p><p>The eye of the tiger sign is most classically associated with <a href="/articles/pantothenate-kinase-associated-neurodegeneration">pantothenate kinase-associated neurodegeneration</a> <sup>1-3 </sup>although it is not pathognomonic particularly in adults <sup>5</sup>. There are no formalised criteria for the sign <sup>6 </sup>and other conditions may demonstrate a similar appearance, such as <a href="/articles/wilson-disease-2">Wilson disease</a> <sup>7</sup>, atypical parkinsonism <sup>8 </sup>and <a href="/articles/organophosphate-poisoning">organophosphate poisoning</a> <sup>9</sup>; it may also be a normal finding on a 3 T magnet <sup>6</sup>. Therefore, caution should be used when interpreting this sign.</p>
Unable to process the form. Check for errors and try again.