Fibrotic non-specific interstitial pneumonitis
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Fibrotic non-specific interstitial pneumonitis is a histological subtype of non-specific interstitial pneumonitis (NSIP). It is considered the more common form 1. This pattern manifests as chronic interstitial inflammation obscured by interstitial fibrosis (with dense collagen), a temporal homogeneous pattern, and occasional focal honeycomb fibrosis 3.
Treatment and prognosis
Corticosteroid can be given but it carries a worse prognosis than the cellular type.
Differential diagnosis
The key imaging differential is a UIP pattern
- according to one study 62% of patients with UIP showed subpleural predominance whereas 55% of patients with fibrotic NSIP exhibited random distribution 4
-<p><strong>Fibrotic non-specific interstitial pneumonitis</strong> is a histological subtype of <a href="/articles/non-specific-interstitial-pneumonia-1">non-specific interstitial pneumonitis (NSIP)</a>. It is considered the more common form <sup>1</sup>. This pattern manifests as chronic interstitial inflammation obscured by interstitial fibrosis (with dense collagen), a temporal homogeneous pattern, and occasional focal <a href="/articles/honeycombing-lungs">honeycomb</a> fibrosis <sup>3</sup>.</p><h4>Treatment and prognosis</h4><p>Corticosteroid can be given but it carries a worse prognosis than the cellular type. </p><h4>Differential diagnosis</h4><p>The key imaging differential is a <a href="/articles/revised-diagnostic-hrct-criteria-for-usual-interstitial-pneumonia-pattern-2011">UIP pattern</a></p><ul><li>according to one study 62% of patients with UIP showed subpleural predominance whereas 55% of patients with fibrotic NSIP exhibited random distribution <sup>4</sup>- +<p><strong>Fibrotic non-specific interstitial pneumonitis</strong> is a histological subtype of <a href="/articles/non-specific-interstitial-pneumonia-1">non-specific interstitial pneumonitis (NSIP)</a>. It is considered the more common form <sup>1</sup>. This pattern manifests as chronic interstitial inflammation obscured by interstitial fibrosis (with dense collagen), a temporal homogeneous pattern, and occasional focal <a href="/articles/honeycombing-lungs">honeycomb</a> fibrosis <sup>3</sup>.</p><h4>Treatment and prognosis</h4><p>Corticosteroid can be given but it carries a worse prognosis than the cellular type. </p><h4>Differential diagnosis</h4><p>The key imaging differential is a <a href="/articles/diagnostic-hrct-criteria-for-usual-interstitial-pneumonia-uip-pattern-atsersjrsalat-2018">UIP pattern</a></p><ul><li>according to one study 62% of patients with UIP showed subpleural predominance whereas 55% of patients with fibrotic NSIP exhibited random distribution <sup>4</sup>
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