Gallium-68 DOTATATE
Updates to Article Attributes
68Ga-DOTATATE is a PET radiotracer that is useful for evaluating primary and metastatic well-differentiated neuroendocrine tumours. It is a form of somatostatin-receptor (SSTR) functional imaging and most often combined with cross-sectional imaging in the form of PET/CT.
Terminology
68Ga-DOTA-TATE is synthesised from three main components: a gallium radiotracer, linked, via a chemical chelator, known as tetraazacyclododecane-tetraacetic acid (DOTA), to the short-chain peptide Tyr3-octreotate (TATE).
Pathology
68Ga-DOTATATE has shown improved accuracy for detection relative to indium-111 pentetreotide SPECT/CT 1. It binds SSTR subtype 2 and binds 100 times more avidly than 111In-pentetreotide 2.
There are other forms:
- DOTATOC: DOTA-d-Phe1-Tyr3-octreotide
- DOTANOC: DOTA-1-Nal3-octreotide
These have affinity for different somatostatin receptors, SSTR subtypes 3 and 5 and SSTR subtype 5, respectively 3.
Radiographic features
There is normal 68Ga-DOTATATE uptake in the pituitary gland, spleen, liver, adrenal glands, and urinary tract 4.
The salivary glands and thyroid show faint to mild homogeneous uptake 4.
-<p><strong><sup>68</sup>Ga-DOTATATE<strong></strong></strong> is a <a title="PET" href="/articles/positron-emission-tomography">PET</a> radiotracer that is useful for evaluating primary and metastatic well-differentiated <a href="/articles/neuroendocrine-tumours">neuroendocrine tumours</a>. It is a form of somatostatin-receptor (SSTR) functional imaging and most often combined with cross-sectional imaging in the form of PET/CT.</p><h4>Terminology</h4><p><sup>68</sup>Ga-DOTA-TATE is synthesised from three main components: a gallium radiotracer, linked, via a chemical chelator, known as tetraazacyclododecane-tetraacetic acid (DOTA), to the short-chain peptide Tyr3-octreotate (TATE). </p><h4>Pathology</h4><p><sup>68</sup>Ga-DOTATATE has shown improved accuracy for detection relative to <a href="/articles/indium-111-oncoscint-1">indium-111 pentetreotide</a> SPECT/CT <sup>1</sup>. It binds SSTR subtype 2 and binds 100 times more avidly than <sup>111</sup>In-pentetreotide <sup>2</sup>.</p><p>There are other forms:</p><ul>- +<p><strong><sup>68</sup>Ga-DOTATATE<strong></strong></strong> is a <a href="/articles/positron-emission-tomography">PET</a> radiotracer that is useful for evaluating primary and metastatic well-differentiated <a href="/articles/neuroendocrine-tumours">neuroendocrine tumours</a>. It is a form of somatostatin-receptor (SSTR) functional imaging and most often combined with cross-sectional imaging in the form of PET/CT.</p><h4>Terminology</h4><p><sup>68</sup>Ga-DOTA-TATE is synthesised from three main components: a gallium radiotracer, linked, via a chemical chelator, known as tetraazacyclododecane-tetraacetic acid (DOTA), to the short-chain peptide Tyr3-octreotate (TATE). </p><h4>Pathology</h4><p><sup>68</sup>Ga-DOTATATE has shown improved accuracy for detection relative to <a title="indium-111 pentetreotide" href="/articles/indium-111-pentetreotide">indium-111 pentetreotide</a> SPECT/CT <sup>1</sup>. It binds SSTR subtype 2 and binds 100 times more avidly than <sup>111</sup>In-pentetreotide <sup>2</sup>.</p><p>There are other forms:</p><ul>
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