Gardner syndrome
Updates to Article Attributes
Body
was changed:
Gardner syndrome is one of the polyposis syndromes. It is characterised by:
- familial adenopolyposis (FAP)
- multiple osteomas especially of the mandible, skull and long bones
- epidermal cysts
- fibromatoses
- desmoid tumoursof mesentery and anterior abdominal wall
Other abnormalities include:
Pathology
There is an autosomal dominant inheritance in the FAP gene (Chromosome 5q) in a majority of patients but with 20% of cases resulting from new mutations. Extra colonic features often precede the diagnosis of colonic polyps.
History and etymology
First described in 1953 by Gardner and Richards 3.
-<li>fibromatoses</li>- +<li><a title="Musculoskeletal fibromatoses" href="/articles/musculoskeletal-fibromatoses">fibromatoses</a></li>
-<a href="/articles/desmoid-tumour">desmoid tumours</a><a href="/articles/desmoid-tumours-of-abdominal-wall"> </a>of abdominal wall</li>- +<a href="/articles/desmoid-tumour">desmoid tumours</a><a href="/articles/desmoid-tumours-of-abdominal-wall"> </a>of mesentery and anterior abdominal wall </li>
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