Glioblastoma NOS
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Glioblastoma NOS (not otherwise specified) is a diagnosis in the current (2016) WHO classification of CNS tumours and denotes a diffuse glioma with astrocytic features and anaplasia, microvascular proliferation and/or necrosis consistent with a WHO grade IV glioblastoma but with inconclusive or unavailable IDH mutation status 1.
As such, much of the older literature on glioblastomas should be considered to describe glioblastoma NOS.
As most glioblastoma NOS are in actuality glioblastoma IDH wild-type (just with unavailable IDH status), they are discussed as part of the generic glioblastoma article.
-<p><strong>Glioblastoma NOS</strong> (not otherwise specified) is a diagnosis in the current (2016) <a href="/articles/who-classification-of-cns-tumours-1">WHO classification of CNS tumours</a> and denotes a diffuse glioma with astrocytic features and anaplasia, microvascular proliferation and/or necrosis consistent with a WHO grade IV <a href="/articles/glioblastoma">glioblastoma</a> but with inconclusive or unavailable <a href="/articles/isocitrate-dehydrogenase-idh">IDH mutation</a> status <sup>1</sup>. </p><p>As such, much of the older literature on glioblastomas should be considered to describe glioblastoma NOS.</p>- +<p><strong>Glioblastoma NOS</strong> (not otherwise specified) is a diagnosis in the current (2016) <a href="/articles/who-classification-of-cns-tumours-1">WHO classification of CNS tumours</a> and denotes a diffuse glioma with astrocytic features and anaplasia, microvascular proliferation and/or necrosis consistent with a WHO grade IV <a href="/articles/glioblastoma">glioblastoma</a> but with inconclusive or unavailable <a href="/articles/isocitrate-dehydrogenase-idh">IDH mutation</a> status <sup>1</sup>. </p><p>As such, much of the older literature on glioblastomas should be considered to describe glioblastoma NOS.</p><p>As most glioblastoma NOS are in actuality glioblastoma IDH wild-type (just with unavailable IDH status), they are discussed as part of the generic <a href="/articles/glioblastoma">glioblastoma</a> article. </p>
References changed:
- 1. Louis DN, Ohgaki H, Wiestler OD et-al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114 (2): 97-109. <a href="http://link.springer.com/article/10.1007/s00401-007-0243-4/fulltext.html">Acta Neuropathol. (full text)</a> - <a href="http://dx.doi.org/10.1007/s00401-007-0243-4">doi:10.1007/s00401-007-0243-4</a> - <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1929165">Free text at pubmed</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/17618441">Pubmed citation</a><span class="ref_v3"></span>
Systems changed:
- Central Nervous System
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