Granulomatosis with polyangiitis (upper respiratory tract manifestations)
Updates to Article Attributes
Title
was changed:
Granulomatosis with polyangiitis: upper respiratory tract manifestations
Body
was changed:
The upper respiratory tract manifestations of granulomatosis with polyangiitis (GPA) (formerly known as Wegener granulomatosis) isare common, affecting most patients.
Epidemiology
The majority of patients of GPA have upper respiratory tract involvement, most commonly presenting with rhinitis and epistaxis1,3.
Pathology
GPA manifests in the upper respiratory tract with 1-3:
- sinusitis/mastoiditis/otitis
- sinonasal mucosal ulcers
- bone deformities, e.g. nasal septal perforation, nasal saddle deformity
- subglottic stenosis
Radiographic features
CT
- sinonasal mucosal thickening +/- air-fluid levels +/- soft tissue nodules
- bony erosions, in particular affecting lamina papyracea, nasal septum, and lateral nasal cavity wall
Differential diagnosis
- chronic sinusitis
- other causes of nasal septal perforation
-<p>The <strong>upper respiratory tract manifestations</strong> of <strong>granulomatosis with polyangiitis (GPA) </strong>(formerly known as Wegener granulomatosis) is common, </p><h4>Epidemiology</h4><p>The majority of patients of GPA have upper respiratory tract involvement, most commonly presenting with rhinitis and epistaxis 1,3.</p><h4>Pathology</h4><p>GPA manifests in the upper respiratory tract with <sup>1-3</sup>:</p><ul>- +<p>The <strong>upper respiratory tract manifestations</strong> of <strong>granulomatosis with polyangiitis (GPA) </strong>(formerly known as Wegener granulomatosis) are common, affecting most patients.</p><h4>Epidemiology</h4><p>The majority of patients of <a href="/articles/granulomatosis-with-polyangiitis">GPA</a> have upper respiratory tract involvement, most commonly presenting with rhinitis and <a title="Epistaxis" href="/articles/epistaxis">epistaxis</a> <sup>1,3</sup>.</p><h4>Pathology</h4><p>GPA manifests in the upper respiratory tract with <sup>1-3</sup>:</p><ul>
-<li>bone deformities, e.g. <a title="Nasal septal perforation" href="/articles/nasal-septal-perforation-2">nasal septal perforation</a>, nasal saddle deformity</li>- +<li>bone deformities, e.g. <a href="/articles/nasal-septal-perforation-2">nasal septal perforation</a>, nasal saddle deformity</li>
-<li>bony erosions, in particular affecting lamina papyracea, nasal septum, and lateral nasal cavity wall</li>- +<li>bony erosions, in particular affecting <a title="lamina papyracea" href="/articles/lamina-papyracea">lamina papyracea</a>, <a title="nasal septum" href="/articles/nasal-septum">nasal septum</a>, and lateral <a title="Nasal cavity" href="/articles/nasal-cavity">nasal cavity</a> wall</li>
-<li><a title="Chronic sinusitis" href="/articles/chronic-sinusitis">chronic sinusitis</a></li>-<li>other causes of <a title="Nasal septal perforation" href="/articles/nasal-septal-perforation-2">nasal septal perforation</a>- +<li><a href="/articles/chronic-sinusitis">chronic sinusitis</a></li>
- +<li>other causes of <a href="/articles/nasal-septal-perforation-2">nasal septal perforation</a>
References changed:
- 3. Benoudiba F, Marsot-Dupuch K, Rabia MH et-al. Sinonasal Wegener's granulomatosis: CT characteristics. Neuroradiology. 2003;45 (2): 95-9. <a href="http://dx.doi.org/10.1007/s00234-002-0885-9">doi:10.1007/s00234-002-0885-9</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/12592492">Pubmed citation</a><span class="auto"></span>
- 1. Martinez F, Chung JH, Digumarthy SR et-al. Common and uncommon manifestations of Wegener granulomatosis at chest CT: radiologic-pathologic correlation. Radiographics. 2012;32 (1): 51-69. <a href="http://dx.doi.org/10.1148/rg.321115060">doi:10.1148/rg.321115060</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/22236893">Pubmed citation</a><span class="auto"></span>
- 2. Provenzale JM, Allen NB. Wegener granulomatosis: CT and MR findings. AJNR Am J Neuroradiol. 1996;17 (4): 785-92. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8730201">Pubmed citation</a><span class="auto"></span>
Systems changed:
- Head & Neck
Tags changed:
- cases
Images Changes:
Image 1 CT (bone window) ( create )
Image 2 CT (non-contrast) ( create )
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