Hypertrophic osteoarthropathy
Updates to Article Attributes
Hypertrophic osteoarthropathy(HO) is a syndrome characterised by periosteal reaction involving the diaphysis and metadiaphysis of the long bones of distal extremities without an underlying bone lesion. ClubbingThere is a broad range of manifestations, although it tends to be symmetric and involving the appendicular skeleton. Accompanying abnormal soft tissue proliferation is variable and may result in "clubbing" of the fingers and toes.
HO is seen most commonly in patients with lung, liverlargely considered a secondary phenomenon, and gastrointestinal disorders.When associated withnearly always (95-97% of cases) occurs in the setting of a pulmonary conditionwide variety of other cardiopulmonary, it is termed hypertrophic pulmonary osteoarthropathy (HPOA) and whenPrimary hypertrophic osteoarthropathy (also known asPachydermoperiostosispachydermoperiostosis), is adue to heritable genetic subtypemutation that presentsresults in children or young adults and involves the epiphyseal region of long bonessimilar clinical manifestations, although tend to have more soft tissue findings 5.
Terminology
Hypertrophic osteoarthropathy has been referred to with multiple different terms,given various names including: Pierre-Marie syndrome, Bamberger syndrome, osteoarthropatia hypertrophica,Mankowsky Mankowsky syndrome, and Hagner syndrome.
"Hypertrophic osteoarthropathy" may refer to either the primary or secondary syndrome, although general usage implies the secondary form, given the rarity of primary hypertrophic osteoarthropathy (pachydermoperiostosis).
"Hypertrophic pulmonary osteoarthropathy" specifically refers to HO in the setting of a lung disease, and not from other intrathoracic processes such as mediastinal or pleural disease 5.
Clinical presentation
It is usually painfulHO has variable clinical presentation, ranging from asymptomatic morphologic and associated with clubbingradiographic findings to pain accompanying the changes of the fingers orand toes5.
Pathology
The causesprimary form of hypertrophic osteoarthropathy is due to mutations in the genes encoding 15-hydroxyprostaglandin dehydrogenase and solute carrier organic anion transporter family member 2A1, resulting in abnormal accumulation of prostaglandin E25.
Although the cause of secondary hypertrophic osteoarthropathy is not established, a similar mechanism involving abnormally elevated levels of circulated hormones has been proposed as a potential etiology. Alternatively, neurogenic etiology has been proposed 5.
Associated disease states include:
- lung
-
bronchogenic carcinoma
- non-small cell lung cancer is the strongest malignant association, particularly squamous cell cancer
- pulmonary lymphoma
- lung abscess
- bronchiectasis
- pulmonary metastases (especially from osteosarcoma)
- pleural fibroma
- mesothelioma
- cyanotic congenital heart disease
-
bronchogenic carcinoma
- gastrointestinal tract and liver
-
familial (pachydermoperiostosis) - idiopathic
Radiographic features
Plain radiograph
Typically seen as long bone metaphyseal and diaphyseal smooth periosteal reaction.
With disease progression, periostitis becomes more prominent or multilayered and extends to the epiphyses 1.
Nuclear medicine
Tc 99m MDP bone scan
symmetric linear increase in tracer accumulation along diaphyseal and metaphyseal surfaces of long bones 4
"tram-track" appearance
Differential diagnosis
General imaging differential considerations include:
- pachydermoperiostosis (primary hypertrophic osteoarthropathy)
- chronic venous insufficiency
- thyroid acropachy
- hypervitaminosis A
Consider the differential for a smooth periosteal reaction.
On bone scintigraphy, differentials include:
- normal variant
- lateral cortices of the tibiae often appear with a symmetric linear uptake
-
shin splints
- can appear similar, but confined to the tibiae
-
chronic venous insufficiency
- can cause symmetrical periosteal uptake
- usually confined to the lower extremities below the knees
-<p><strong>Hypertrophic osteoarthropathy</strong><em> </em>is characterised by periosteal reaction involving the diaphysis and metadiaphysis of the long bones of distal extremities without an underlying bone lesion. Clubbing of the fingers is seen most commonly in patients with lung, liver, and gastrointestinal disorders.<br>When associated with a pulmonary condition, it is termed <strong>hypertrophic pulmonary osteoarthropathy (HPOA)</strong> and when associated with cancer is considered a <a href="/articles/paraneoplastic-syndromes">paraneoplastic syndrome</a>. <br><strong>Primary hypertrophic osteoarthropathy</strong> (also known as <a title="Pachydermoperiostosis" href="/articles/pachydermoperiostosis">Pachydermoperiostosis</a>) is a genetic subtype that presents in children or young adults and involves the epiphyseal region of long bones.</p><h4>Terminology</h4><p>Hypertrophic osteoarthropathy has been referred to with multiple different terms, including: <strong>Pierre-Marie syndrome</strong>, <strong>Bamberger syndrome</strong>, <strong>osteoarthropatia hypertrophica</strong>, <strong>Mankowsky syndrome</strong> and <strong>Hagner syndrome</strong>.</p><h4>Clinical presentation</h4><p>It is usually painful and associated with clubbing of the fingers or toes. </p><h4>Pathology</h4><p>The causes of <strong>hypertrophic osteoarthropathy</strong> include:</p><ul>- +<p><strong>Hypertrophic osteoarthropathy</strong><em> </em>(HO) is a syndrome characterised by periosteal reaction of the long bones without underlying bone lesion. There is a broad range of manifestations, although it tends to be symmetric and involving the appendicular skeleton. Accompanying abnormal soft tissue proliferation is variable and may result in "clubbing" of the fingers and toes.</p><p>HO is largely considered a secondary phenomenon, and nearly always (95-97% of cases) occurs in the setting of a wide variety of other cardiopulmonary, gastrointestinal, endocrine, haematologic, and inflammatory conditions <sup>5</sup>. When associated with cancer is considered a <a href="/articles/paraneoplastic-syndromes">paraneoplastic syndrome</a>. A primary form, <a title="Pachydermoperiostosis" href="/articles/pachydermoperiostosis">pachydermoperiostosis</a>, is due to heritable genetic mutation that results in similar clinical manifestations, although tend to have more soft tissue findings <sup>5</sup>.</p><h4>Terminology</h4><p>Hypertrophic osteoarthropathy has been given various names including Pierre-Marie syndrome, Bamberger syndrome, osteoarthropatia hypertrophica, Mankowsky syndrome, and Hagner syndrome.</p><p>"<em>Hypertrophic osteoarthropathy</em>" may refer to either the primary or secondary syndrome, although general usage implies the secondary form, given the rarity of primary hypertrophic osteoarthropathy (<a href="/articles/pachydermoperiostosis">pachydermoperiostosis</a>).</p><p>"<em>Hypertrophic pulmonary osteoarthropathy</em>" specifically refers to HO in the setting of a lung disease, and not from other intrathoracic processes such as mediastinal or pleural disease <sup>5</sup>.</p><h4>Clinical presentation</h4><p>HO has variable clinical presentation, ranging from asymptomatic morphologic and radiographic findings to pain accompanying the changes of the fingers and toes <sup>5</sup>.</p><h4>Pathology</h4><p>The primary form of hypertrophic osteoarthropathy is due to mutations in the genes encoding 15-hydroxyprostaglandin dehydrogenase and solute carrier organic anion transporter family member 2A1, resulting in abnormal accumulation of prostaglandin E<sub>2</sub> <sup>5</sup>.</p><p>Although the cause of secondary hypertrophic osteoarthropathy is not established, a similar mechanism involving abnormally elevated levels of circulated hormones has been proposed as a potential etiology. Alternatively, neurogenic etiology has been proposed <sup>5</sup>.</p><p>Associated disease states include:</p><ul>
-<li>familial (<a title="pachydermoperiostosis" href="/articles/pachydermoperiostosis">pachydermoperiostosis</a>)</li>
References changed:
- 5. Yap F, Skalski M, Patel D et al. Hypertrophic Osteoarthropathy: Clinical and Imaging Features. Radiographics. 2017;37(1):157-95. <a href="https://doi.org/10.1148/rg.2017160052">doi:10.1148/rg.2017160052</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/27935768">Pubmed</a>
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