Idiopathic pneumonia syndrome
Updates to Article Attributes
Idiopathic pneumonia syndrome (IPS) refers to diffuse lung injury which can occur following haematopeotic stem cell transplantation where neither an infectious nor non-infectious aetiology can be found. It
Epidemiology
The incidence of IPS is thought to be around 12% following haematopoetic stem cell transplantation. Its
Clinical presentation
Clinical presentation can vary from being asymptomatic to full blown acute respiratory distress syndrome. Its median onset time is around 40-50 days following transplantation, but there is an early peak in the first 14 days., followed by a lower but consistent incidence up to around 80-100 days.
Clinical presentation
Clinical presentation can vary from being asymptomatic to full blown acute respiratory distress syndrome.
Pathology
Its aetiology is thought to be multifactorial inclusive of chemoradiotherapeutic insults and graft versus host disease 4.
There are two main histopathological patterns
- interstitial pneumonitis
- diffuse alveolar damage
.
Radiographic features
Plain film / CT
Would
-
would typically show diffuse airspace and/or intestinal infiltrative opacification 4
.
See also
-<p><strong>Idiopathic pneumonia syndrome (IPS) </strong>refers to diffuse lung injury which can occur following haematopeotic stem cell transplantation where neither an infectious nor non-infectious aetiology can be found. It incidence is thought to be around 12% following haematopoetic stem cell transplantation. Its median onset time is around 40-50 days following transplantation, but there is an early peak in the first 14 days. followed by a lower but consistent incidence up to around 80-100 days.</p><h4>Clinical presentation</h4><p>Clinical presentation can vary from being asymptomatic to full blown <a href="/articles/adult-respiratory-distress-syndrome">acute respiratory distress syndrome</a>. </p><h4>Pathology</h4><p>Its aetiology is thought to be multifactorial inclusive of chemoradiotherapeutic insults and <a title="Graft versus host disease (GvHD)" href="/articles/graft-verses-host-disease">graft versus host disease</a> <sup>4</sup>.</p><p>There are two main histopathological patterns</p><ul>- +<p><strong>Idiopathic pneumonia syndrome (IPS) </strong>refers to diffuse lung injury which can occur following haematopeotic stem cell transplantation where neither an infectious nor non-infectious aetiology can be found.</p><h4>Epidemiology</h4><p>The incidence of IPS is thought to be around 12% following haematopoetic stem cell transplantation. </p><h4>Clinical presentation</h4><p>Clinical presentation can vary from being asymptomatic to full blown <a href="/articles/adult-respiratory-distress-syndrome">acute respiratory distress syndrome</a>. Its median onset time is around 40-50 days following transplantation, but there is an early peak in the first 14 days, followed by a lower but consistent incidence up to around 80-100 days.</p><h4>Pathology</h4><p>Its aetiology is thought to be multifactorial inclusive of chemoradiotherapeutic insults and <a href="/articles/graft-verses-host-disease">graft versus host disease</a> <sup>4</sup>. <span style="line-height:1.6em">There are two main histopathological patterns</span></p><ul>
-<li>diffuse alveolar damage.</li>-</ul><h4>Radiographic features</h4><h5>Plain film / CT</h5><p>Would typically show diffuse airspace and/or intestinal infiltrative opacification <sup>4</sup>.</p><h4>See also</h4><ul><li><a title="Pulmonary complications following haematopoetic stem cell transplantation" href="/articles/thoracic-complications-of-haematopoetic-stem-cell-transplantation">pulmonary complications of haematopoetic stem cell transplantation</a></li></ul><p> </p>- +<li>diffuse alveolar damage</li>
- +</ul><h4>Radiographic features</h4><h5>Plain film / CT</h5><ul><li>would typically show diffuse airspace and/or intestinal infiltrative opacification <sup>4</sup>
- +</li></ul><h4>See also</h4><ul><li><a href="/articles/thoracic-complications-of-haematopoetic-stem-cell-transplantation">pulmonary complications of haematopoetic stem cell transplantation</a></li></ul>
Sections changed:
- Syndromes
Systems changed:
- Chest
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