Law of Bergonié and Tribondeau

Last revised by Artemiy Balakin on 7 May 2024

Citation, DOI, disclosures and article data

Citation:

Sciacca F, Balakin A, Moore C, Law of Bergonié and Tribondeau. Reference article, Radiopaedia.org (Accessed on 29 May 2024) https://doi.org/10.53347/rID-72348

DOI:

https://doi.org/10.53347/rID-72348

Permalink:

https://radiopaedia.org/articles/72348

rID:

72348

Article created:

21 Nov 2019, Francesco Sciacca ◉

Disclosures:

At the time the article was created Francesco Sciacca had no recorded disclosures.

View Francesco Sciacca's current disclosures

Last revised:

7 May 2024, Artemiy Balakin

Disclosures:

At the time the article was last revised Artemiy Balakin had no financial relationships to ineligible companies to disclose.

View Artemiy Balakin's current disclosures

Revisions:

5 times, by 3 contributors - see full revision history and disclosures

Sections:

Imaging Technology

Tags:

radiosensitivity

Synonyms:

Radiosensitivity law

The law of Bergonie and Tribondeau is that the radiosensitivity of a biological tissue is directly proportional to the mitotic activity and inversely proportional to the degree of differentiation of its cells. This law underpins the field of radiation-oncology, although such a general law may not apply precisely in all cases.

Usually neoplastic cells are more radiosensitive than the cells from which they originate; in fact, they reproduce much faster than healthy cells.

Cellular differentiation describes the extent to which a tumor resembles the normal tissue from which it derives. The more it differs from healthy tissue, the greater its radiosensitivity will be.