Loeys-Dietz syndrome
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Loeys-Dietz syndrome (LDS) is an autosomal dominant genetic syndrome which has many features similar to Marfan syndrome.
The syndrome is thought to have classical triad of 1
- arterial tortuosity and aneurysms
- hypertelorism
- bifid uvula or cleft palate
Pathology
It is caused by mutations in the genes encoding transforming growth factor beta receptor 1 (TGFBR1) or 2 (TGFBR2).
Sub types
LDS can be subdivided in LDS type I (LDSI) and type II (LDSII) on the basis of the presence or the absence of cranio-facialcraniofacial involvement
Etymology
It is named after Harry C. Dietz : American, an American (US) physicanphysician and Bart L. Loeys 1 : a Belgian physician.
-</ul><h4>Pathology</h4><p>It is caused by mutations in the genes encoding transforming growth factor beta receptor 1 (TGFBR1) or 2 (TGFBR2).</p><h5>Sub types</h5><p>LDS can be subdivided in LDS type I (LDSI) and type II (LDSII) on the basis of the presence or the absence of cranio-facial involvement</p><h4>Etymology</h4><p>It is named after <strong>Harry C. Dietz</strong> : American (US) physican and <strong>Bart L. Loeys</strong><sup> 1</sup> : Belgian physician.</p>- +</ul><h4>Pathology</h4><p>It is caused by mutations in the genes encoding transforming growth factor beta receptor 1 (TGFBR1) or 2 (TGFBR2).</p><h5>Sub types</h5><p>LDS can be subdivided in LDS type I (LDSI) and type II (LDSII) on the basis of the presence or the absence of craniofacial involvement</p><h4>Etymology</h4><p>It is named after <strong>Harry C. Dietz</strong>, an American (US) physician and <strong>Bart L. Loeys</strong><sup> 1</sup> a Belgian physician.</p>
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