N-acetylaspartate (NAA) peak
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N-acetylaspartate (NAA) is one of the more important compounds assessed on MR spectroscopy, and resonates at 2.0 ppm chemical shift (its concentration in healthy adults is 8-10 mM) 1. The synthesis of NAA, adenosine diphosphate-dependent, occurs in the mitochondria and is adenosine diphosphate-dependent 2 2.
NAA is the acetylated form of the amino acid, aspartate, which is found in high concentrations in neurons and is a marker of neuronal viability. It is therefore reduced in any process that destroys neurons, such as high grade tumours, radionecrosis, non-neuronal tumours (e.g. cerebral metastases and primary CNS lymphoma).
-<p><strong>N-acetylaspartate (NAA)</strong> is one of the more important compounds assessed on <a href="/articles/mr-spectroscopy-1">MR spectroscopy</a>, and resonates at 2.0 ppm chemical shift (its concentration in healthy adults is 8-10 mM) <sup>1</sup>. The synthesis of NAA occurs in the mitochondria and is adenosine diphosphate-dependent<sup> 2</sup>.</p><p>NAA is the acetylated form of the <a href="/articles/amino-acids-1">amino acid</a>, aspartate, which is found in high concentrations in neurons and is a marker of neuronal viability. It is therefore reduced in any process that destroys neurons, such as <a href="/articles/glioblastoma">high grade tumours</a>, <a href="/articles/cerebral-radiation-necrosis-1">radionecrosis</a>, non-neuronal tumours (e.g. <a href="/articles/brain-metastases">cerebral metastases</a> and <a href="/articles/primary-cns-lymphoma">primary CNS lymphoma</a>).</p>- +<p><strong>N-acetylaspartate (NAA)</strong> is one of the more important compounds assessed on <a href="/articles/mr-spectroscopy-1">MR spectroscopy</a>, and resonates at 2.0 ppm chemical shift (its concentration in healthy adults is 8-10 mM) <sup>1</sup>. The synthesis of NAA, adenosine diphosphate-dependent, occurs in the mitochondria<sup> 2</sup>.</p><p>NAA is the acetylated form of the <a href="/articles/amino-acids-1">amino acid</a>, aspartate, which is found in high concentrations in neurons and is a marker of neuronal viability. It is therefore reduced in any process that destroys neurons, such as <a href="/articles/glioblastoma">high grade tumours</a>, <a href="/articles/cerebral-radiation-necrosis-1">radionecrosis</a>, non-neuronal tumours (e.g. <a href="/articles/brain-metastases">cerebral metastases</a> and <a href="/articles/primary-cns-lymphoma">primary CNS lymphoma</a>).</p>
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